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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2039
Target Type SINGLE PROTEIN
Preferred Name Monoamine oxidase B
Synonyms Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine oxidase type B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Amine oxidase [flavin-containing] B SINGLE PROTEIN P27338

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095205 Monoamine oxidase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL48582 SAFINAMIDE MESYLATE Monoamine oxidase B inhibitor 4 FDA Other
CHEMBL972 SELEGILINE Monoamine oxidase B inhibitor 4 FDA
CHEMBL396778 SAFINAMIDE Monoamine oxidase B inhibitor 4 FDA Other
CHEMBL1200904 SELEGILINE HYDROCHLORIDE Monoamine oxidase B inhibitor 4 FDA
CHEMBL1201142 RASAGILINE MESYLATE Monoamine oxidase B inhibitor 4 FDA
CHEMBL2107771 RALFINAMIDE Monoamine oxidase B inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000069535
Ensembl ENSG00000069535
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005740 (mitochondrial envelope)
GO:0005741 (mitochondrial outer membrane)
GO:0005743 (mitochondrial inner membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0008131 (primary amine oxidase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0042803 (protein homodimerization activity)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0009636 (response to toxic substance)
GO:0010044 (response to aluminum ion)
GO:0010269 (response to selenium ion)
GO:0014063 (negative regulation of serotonin secretion)
GO:0021762 (substantia nigra development)
GO:0032496 (response to lipopolysaccharide)
GO:0042420 (dopamine catabolic process)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0045964 (positive regulation of dopamine metabolic process)
GO:0048545 (response to steroid hormone)
GO:0050665 (hydrogen peroxide biosynthetic process)
GO:0051412 (response to corticosterone)
GO:0055114 (oxidation-reduction process)
Wikipedia Monoamine_oxidase_B

Target Cross References - Protein

canSAR P27338
Human Protein Atlas ENSG00000069535
IntAct P27338
Guide to Pharmacology 2490
Open Targets ENSG00000069535
PharmGKB PA237
Reactome R-HSA-141333 (Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.)
UniProt B2R6R3 B7Z5H3 D3DWC3 P27338 Q7Z6S2

Target Cross References - Domain

InterPro IPR001613 (Flavin_amine_oxidase.)
IPR002937 (Amino_oxidase.)
IPR023753 (FAD/NAD-binding_dom.)
Pfam PF01593 (Amino_oxidase)

Target Cross References - Structure

PDBe 1GOS 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 More...
CREDO 1GOS 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 More...
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