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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2039
Target Type SINGLE PROTEIN
Preferred Name Monoamine oxidase B
Synonyms Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine oxidase type B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Amine oxidase [flavin-containing] B SINGLE PROTEIN P27338

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095205 Monoamine oxidase PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201142 RASAGILINE MESYLATE Monoamine oxidase B inhibitor FDA
CHEMBL972 SELEGILINE Monoamine oxidase B inhibitor FDA
CHEMBL1200904 SELEGILINE HYDROCHLORIDE Monoamine oxidase B inhibitor FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000069535
Ensembl ENSG00000069535
GO Cellular Component GO:0005741 (mitochondrial outer membrane)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0008131 (primary amine oxidase activity)
GO:0009055 (electron carrier activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
Wikipedia Monoamine_oxidase_B

Target Cross References - Protein

canSAR P27338
Human Protein Atlas ENSG00000069535
Guide to Pharmacology 2490 (Monoamine oxidase B)
PharmGKB PA237
Reactome REACT_13433 (Biological oxidations.)
UniProt B2R6R3 D3DWC3 P27338 Q7Z6S2

Target Cross References - Domain

InterPro IPR001613 (Amineoxid_fl.)
IPR002937 (Amino_oxidase.)
Pfam PF01593 (Amino_oxidase)

Target Cross References - Structure

PDBe 1GOS 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 More...
CREDO 1GOS 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 More...
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