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Target Report Card

Target Name and Classification

Target ID CHEMBL2034
Target Type SINGLE PROTEIN
Preferred Name Glucocorticoid receptor
Synonyms GR | GRL | Glucocorticoid receptor | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 1

Target Components

Component Description Relationship Accession
Glucocorticoid receptor SINGLE PROTEIN P04150

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL632 BETAMETHASONE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL635 PREDNISONE Glucocorticoid receptor agonist 4 ISBN PubMed
CHEMBL131 PREDNISOLONE Glucocorticoid receptor agonist 4 PubMed PubMed
CHEMBL650 METHYLPREDNISOLONE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL989 FLUOCINOLONE ACETONIDE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1091 HYDROCORTISONE ACETATE Glucocorticoid receptor agonist 4 DailyMed ISBN
CHEMBL1152 PREDNISOLONE ACETATE Glucocorticoid receptor agonist 4 DailyMed FDA
CHEMBL1161 MOMETASONE FUROATE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL1370 BUDESONIDE Glucocorticoid receptor agonist 4 KEGG PubMed PubMed PubMed
CHEMBL384467 DEXAMETHASONE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL389621 HYDROCORTISONE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL1451 TRIAMCINOLONE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1473 FLUTICASONE PROPIONATE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL1497 BETAMETHASONE VALERATE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1501 FLUOCINONIDE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1504 TRIAMCINOLONE ACETONIDE Glucocorticoid receptor agonist 4 DailyMed
CHEMBL1512 FLUNISOLIDE Glucocorticoid receptor agonist 4 DailyMed ISBN
CHEMBL1549 HYDROCORTISONE CYPIONATE Glucocorticoid receptor agonist 4 DailyMed
CHEMBL1650 CORTISONE ACETATE Glucocorticoid receptor agonist 4 ISBN
CHEMBL1651 DEXAMETHASONE ACETATE Glucocorticoid receptor agonist 4 ISBN PubMed
CHEMBL1676 FLUTICASONE FUROATE Glucocorticoid receptor agonist 4 DailyMed
CHEMBL1683 HYDROCORTISONE BUTYRATE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL1766 DESOXIMETASONE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1159650 CLOBETASOL PROPIONATE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1200342 PARAMETHASONE ACETATE Glucocorticoid receptor agonist 4 ISBN PubMed
CHEMBL1200376 BETAMETHASONE BENZOATE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1200384 BETAMETHASONE DIPROPIONATE Glucocorticoid receptor agonist 4 DailyMed PubMed
CHEMBL1200386 PREDNICARBATE Glucocorticoid receptor agonist 4 PubMed PubMed
CHEMBL1200449 TRIAMCINOLONE DIACETATE Glucocorticoid receptor agonist 4 DailyMed FDA ISBN PubMed
CHEMBL1200495 HYDROCORTISONE SODIUM SUCCINATE Glucocorticoid receptor agonist 4 DailyMed ISBN
CHEMBL1200500 BECLOMETHASONE DIPROPIONATE Glucocorticoid receptor agonist 4 DailyMed
CHEMBL1200538 BETAMETHASONE ACETATE Glucocorticoid receptor agonist 4 ISBN
CHEMBL1200545 DIFLORASONE DIACETATE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1200562 HYDROCORTISONE VALERATE Glucocorticoid receptor agonist 4 DailyMed PubMed
CHEMBL1200600 FLUOROMETHOLONE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1200617 RIMEXOLONE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1200635 HYDROCORTAMATE HYDROCHLORIDE Glucocorticoid receptor agonist 4 ISBN
CHEMBL1200637 DEXAMETHASONE SODIUM PHOSPHATE Glucocorticoid receptor agonist 4 DailyMed
CHEMBL1200732 AMCINONIDE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1200762 BETAMETHASONE SODIUM PHOSPHATE Glucocorticoid receptor agonist 4 ISBN
CHEMBL1200774 FLUPREDNISOLONE Glucocorticoid receptor agonist 4 ISBN PubMed
CHEMBL1200844 METHYLPREDNISOLONE ACETATE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1200845 HALCINONIDE Glucocorticoid receptor agonist 4 PubMed PubMed
CHEMBL1200865 LOTEPREDNOL ETABONATE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1200877 FLUMETHASONE PIVALATE Glucocorticoid receptor agonist 4 ISBN PubMed
CHEMBL1200878 TRIAMCINOLONE HEXACETONIDE Glucocorticoid receptor agonist 4 DailyMed
CHEMBL1200908 HALOBETASOL PROPIONATE Glucocorticoid receptor agonist 4 PubMed PubMed
CHEMBL1200909 PREDNISOLONE TEBUTATE Glucocorticoid receptor agonist 4 ISBN
CHEMBL1200953 HYDROCORTISONE PROBUTATE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL1200968 HYDROCORTISONE SODIUM PHOSPHATE Glucocorticoid receptor agonist 4 ISBN
CHEMBL1200975 CLOCORTOLONE PIVALATE Glucocorticoid receptor agonist 4 DailyMed FDA
CHEMBL1200989 ALCLOMETASONE DIPROPIONATE Glucocorticoid receptor agonist 4 PubMed PubMed
CHEMBL1201012 FLURANDRENOLIDE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1201014 PREDNISOLONE SODIUM PHOSPHATE Glucocorticoid receptor agonist 4 ISBN PubMed
CHEMBL1201064 FLUOROMETHOLONE ACETATE Glucocorticoid receptor agonist 4 DailyMed Expert PubMed
CHEMBL1201081 METHYLPREDNISOLONE SODIUM SUCCINATE Glucocorticoid receptor agonist 4 DailyMed FDA
CHEMBL1201109 DESONIDE Glucocorticoid receptor agonist 4 PubMed PubMed PubMed
CHEMBL1201148 MEPREDNISONE Glucocorticoid receptor agonist 4 Expert ISBN PubMed
CHEMBL1201173 MEDRYSONE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1201749 DIFLUPREDNATE Glucocorticoid receptor agonist 4 PubMed
CHEMBL1201891 DEFLAZACORT Glucocorticoid receptor agonist 4 FDA
CHEMBL1276308 MIFEPRISTONE Glucocorticoid receptor antagonist 4 DailyMed PubMed
CHEMBL2040682 CICLESONIDE Glucocorticoid receptor agonist 4 DailyMed PubMed
CHEMBL2103876 MAPRACORAT Glucocorticoid receptor agonist 3 PubMed
CHEMBL3137304 DAGROCORAT Glucocorticoid receptor modulator 2 Other
CHEMBL3137316 FOSDAGROCORAT Glucocorticoid receptor modulator 2 Other Other
CHEMBL3545391 ORG-34517 Glucocorticoid receptor antagonist 2 PubMed
CHEMBL271220 CORT 108297 Glucocorticoid receptor antagonist 1 Other PubMed
CHEMBL3544957 CORT 125134 Glucocorticoid receptor antagonist 1 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113580
Ensembl ENSG00000113580
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005856 (cytoskeleton)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003723 (RNA binding)
GO:0004883 (glucocorticoid receptor activity)
GO:0005496 (steroid binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0038051 (glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:1990239 (steroid hormone binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007067 (mitotic nuclear division)
GO:0007165 (signal transduction)
GO:0016568 (chromatin modification)
GO:0042921 (glucocorticoid receptor signaling pathway)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043402 (glucocorticoid mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051301 (cell division)
GO:0071383 (cellular response to steroid hormone stimulus)
Wikipedia Glucocorticoid_receptor

Target Cross References - Protein

canSAR P04150
CGD Cortisol resistance
Human Protein Atlas ENSG00000113580
IntAct P04150
Guide to Pharmacology 625
Open Targets ENSG00000113580
PharmGKB PA181
Pharos P04150 (Tclin)
Reactome R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-8849473 (PTK6 Expression.)
UniProt A0ZXF9 B0LPG8 D3DQF4 F5ATB7 P04150 P04151 Q53EP5 Q6N0A4

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001409 (Glcrtcd_rcpt.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF02155 (GCR)

Target Cross References - Structure

PDBe 1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X 4UDC 4UDD 5CBX 5CBY 5CBZ 5CC1 5EMC 5EMP More...
CREDO 1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X 4UDC 4UDD 5CBX 5CBY 5CBZ 5CC1 5EMC 5EMP More...
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