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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2033
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 11A1
Synonyms CYP11A | CYP11A1 | CYPXIA1 | Cholesterol desmolase | Cholesterol side-chain cleavage enzyme, mitochondrial | Cytochrome P450 11A1 | Cytochrome P450(scc)
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 11 > cytochrome p450 family 11a > cytochrome p450 11a1

Target Components

Component Description Relationship Accession
Cholesterol side-chain cleavage enzyme, mitochondrial SINGLE PROTEIN P05108

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL488 AMINOGLUTETHIMIDE Cytochrome P450 11A1 inhibitor 4 FDA
CHEMBL1670 MITOTANE Cytochrome P450 11A1 inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140459
Ensembl ENSG00000140459
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005759 (mitochondrial matrix)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008386 (cholesterol monooxygenase (side-chain-cleaving) activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006700 (C21-steroid hormone biosynthetic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008207 (C21-steroid hormone metabolic process)
GO:0016125 (sterol metabolic process)
GO:0034650 (cortisol metabolic process)
GO:0042359 (vitamin D metabolic process)
GO:0044550 (secondary metabolite biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0071375 (cellular response to peptide hormone stimulus)
Wikipedia Cholesterol_side-chain_cleavage_enzyme

Target Cross References - Protein

canSAR P05108
CGD Adrenal insufficiency, congenital, with 46,XY sex reversal, partial or complete
Human Protein Atlas ENSG00000140459
IntAct P05108
Open Targets ENSG00000140459
PharmGKB PA27089
Reactome R-HSA-196108 (Pregnenolone biosynthesis.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-5579026 (Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR).)
UniProt A8K8D5 B3KPU8 G3XAD7 P05108 Q15081 Q16805 Q8N1A7

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR033283 (CYP11A1.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 3N9Y 3N9Z 3NA0 3NA1
CREDO 3N9Y 3N9Z 3NA0 3NA1
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