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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2032
Target Type SINGLE PROTEIN
Preferred Name Growth hormone-releasing hormone receptor
Synonyms GHRH receptor | GHRHR | GRF receptor | GRFR | Growth hormone-releasing factor receptor | Growth hormone-releasing hormone receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family b g protein-coupled receptor > peptide receptor (family b gpcr) > glucagon-like receptor > growth hormone-releasing hormone receptor

Target Components

Component Description Relationship Accession
Growth hormone-releasing hormone receptor SINGLE PROTEIN Q02643

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201490 SERMORELIN ACETATE Growth hormone-releasing hormone receptor agonist 4 PubMed
CHEMBL2111290 TESAMORELIN ACETATE Growth hormone-releasing hormone receptor agonist 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106128
Ensembl ENSG00000106128
GO Cellular Component GO:0005637 (nuclear inner membrane)
GO:0005640 (nuclear outer membrane)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016363 (nuclear matrix)
GO:0030141 (secretory granule)
GO:0042383 (sarcolemma)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0016520 (growth hormone-releasing hormone receptor activity)
GO:0017046 (peptide hormone binding)
GO:0019838 (growth factor binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007595 (lactation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008340 (determination of adult lifespan)
GO:0019933 (cAMP-mediated signaling)
GO:0021984 (adenohypophysis development)
GO:0030104 (water homeostasis)
GO:0030252 (growth hormone secretion)
GO:0030816 (positive regulation of cAMP metabolic process)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0030879 (mammary gland development)
GO:0032868 (response to insulin)
GO:0032869 (cellular response to insulin stimulus)
GO:0033143 (regulation of intracellular steroid hormone receptor signaling pathway)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042445 (hormone metabolic process)
GO:0043567 (regulation of insulin-like growth factor receptor signaling pathway)
GO:0043568 (positive regulation of insulin-like growth factor receptor signaling pathway)
GO:0043627 (response to estrogen)
GO:0046010 (positive regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0046887 (positive regulation of hormone secretion)
GO:0048469 (cell maturation)
GO:0048609 (multicellular organismal reproductive process)
GO:0051246 (regulation of protein metabolic process)
GO:0051384 (response to glucocorticoid)
GO:0060124 (positive regulation of growth hormone secretion)
GO:0060133 (somatotropin secreting cell development)
GO:0071333 (cellular response to glucose stimulus)
Wikipedia Growth-hormone-releasing_hormone_receptor

Target Cross References - Protein

canSAR Q02643
CGD Isolated growth hormone deficiency, type 1B
Human Protein Atlas ENSG00000106128
Guide to Pharmacology 247
Open Targets ENSG00000106128
PharmGKB PA28676
Pharos Q02643 (Tclin)
Reactome R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-420092 (Glucagon-type ligand receptors.)
UniProt Q02643 Q99863

Target Cross References - Domain

InterPro IPR000832 (GPCR_2_secretin-like.)
IPR001879 (GPCR_2_extracellular_dom.)
IPR003288 (GPCR_2_GHRH_rcpt.)
IPR017981 (GPCR_2-like.)
IPR017983 (GPCR_2_secretin-like_CS.)
Pfam PF00002 (7tm_2)
PF02793 (HRM)

Target Cross References - Structure

PDBe 2XDG
CREDO 2XDG
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