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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2024
Target Type SINGLE PROTEIN
Preferred Name Follicle stimulating hormone receptor
Synonyms FSH-R | FSHR | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > glycohormone receptor > glycohormone receptor

Target Components

Component Description Relationship Accession
Follicle-stimulating hormone receptor SINGLE PROTEIN P23945

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201520 UROFOLLITROPIN Follicle stimulating hormone receptor agonist 4 DailyMed
CHEMBL1201692 HUMAN FSH Follicle stimulating hormone receptor agonist 4 DailyMed DailyMed FDA FDA PubMed PubMed
CHEMBL2108427 MENOTROPINS Follicle stimulating hormone receptor agonist 4 DailyMed FDA PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170820
Ensembl ENSG00000170820
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004963 (follicle-stimulating hormone receptor activity)
GO:0005515 (protein binding)
GO:0008528 (G-protein coupled peptide receptor activity)
GO:0016500 (protein-hormone receptor activity)
GO Biological Process GO:0001545 (primary ovarian follicle growth)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007283 (spermatogenesis)
GO:0007292 (female gamete generation)
GO:0008406 (gonad development)
GO:0008584 (male gonad development)
GO:0008585 (female gonad development)
GO:0009755 (hormone-mediated signaling pathway)
GO:0010738 (regulation of protein kinase A signaling)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0042699 (follicle-stimulating hormone signaling pathway)
GO:0045670 (regulation of osteoclast differentiation)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
Wikipedia Follicle-stimulating_hormone_receptor

Target Cross References - Protein

CGD Ovarian hyperstimulation syndrome; Ovarian dysgenesis 1
Human Protein Atlas ENSG00000170820
IntAct P23945
Guide to Pharmacology 253
Open Targets ENSG00000170820
PharmGKB PA28386
Pharos P23945 (Tclin)
Reactome R-HSA-375281 (Hormone ligand-binding receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt A0A0A0MSC5 A8K947 G5CBS7 G5E967 J3KQ00 P23945 Q05AH0 Q16225 Q4QRJ3 Q4ZFZ2 Q53RW2

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000372 (LRRNT.)
IPR002131 (Gphrmn_rcpt_fam.)
IPR002272 (FSH_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR024635 (GnHR_TM.)
IPR026906 (LRR_5.)
IPR032675 (L_dom-like.)
IPR034298 (TSHR/LHCGR/FSHR.)
Pfam PF00001 (7tm_1)
PF01462 (LRRNT)
PF12369 (GnHR_trans)
PF13306 (LRR_5)

Target Cross References - Structure

PDBe 1XWD 4AY9 4MQW
CREDO 1XWD 4AY9 4MQW
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