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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2023
Target Type SINGLE PROTEIN
Preferred Name Catechol O-methyltransferase
Synonyms COMT | Catechol O-methyltransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Catechol O-methyltransferase SINGLE PROTEIN P21964

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL953 ENTACAPONE Catechol O-methyltransferase inhibitor 4 DailyMed
CHEMBL1324 TOLCAPONE Catechol O-methyltransferase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000093010
Ensembl ENSG00000093010
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043197 (dendritic spine)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0044297 (cell body)
GO:0045211 (postsynaptic membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0005515 (protein binding)
GO:0008168 (methyltransferase activity)
GO:0008171 (O-methyltransferase activity)
GO:0016206 (catechol O-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0102084 (L-dopa O-methyltransferase activity)
GO:0102938 (orcinol O-methyltransferase activity)
GO Biological Process GO:0006584 (catecholamine metabolic process)
GO:0007565 (female pregnancy)
GO:0007612 (learning)
GO:0007614 (short-term memory)
GO:0008210 (estrogen metabolic process)
GO:0009712 (catechol-containing compound metabolic process)
GO:0014070 (response to organic cyclic compound)
GO:0016036 (cellular response to phosphate starvation)
GO:0032259 (methylation)
GO:0032496 (response to lipopolysaccharide)
GO:0032502 (developmental process)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0042135 (neurotransmitter catabolic process)
GO:0042417 (dopamine metabolic process)
GO:0042420 (dopamine catabolic process)
GO:0042424 (catecholamine catabolic process)
GO:0042493 (response to drug)
GO:0043627 (response to estrogen)
GO:0045963 (negative regulation of dopamine metabolic process)
GO:0048265 (response to pain)
GO:0048609 (multicellular organismal reproductive process)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0050668 (positive regulation of homocysteine metabolic process)
GO:0051930 (regulation of sensory perception of pain)
Wikipedia Catechol-O-methyl_transferase

Target Cross References - Protein

canSAR P21964
CGD Medication response, association with
Human Protein Atlas ENSG00000093010
IntAct P21964
Guide to Pharmacology 2472
Open Targets ENSG00000093010
PharmGKB PA117
Reactome R-HSA-156581 (Methylation.)
R-HSA-379397 (Enzymatic degradation of dopamine by COMT.)
R-HSA-379398 (Enzymatic degradation of Dopamine by monoamine oxidase.)
UniProt A8MPV9 P21964 Q6IB07 Q6ICE6 Q9BWC7

Target Cross References - Domain

InterPro IPR002935 (O-MeTrfase_3.)
IPR017128 (Catechol_O-MeTrfase_euk.)
IPR029063 (SAM-dependent_MTases.)
Pfam PF01596 (Methyltransf_3)

Target Cross References - Structure

PDBe 3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA
CREDO 3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA
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