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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2016
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor IX
Synonyms Christmas factor | Coagulation factor IX | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | PTC | Plasma thromboplastin component
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Coagulation factor IX SINGLE PROTEIN P00740

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111424 Coagulation factor IX and X SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101981
Ensembl ENSG00000101981
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006465 (signal peptide processing)
GO:0006508 (proteolysis)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0007596 (blood coagulation)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0007598 (blood coagulation, extrinsic pathway)
GO:0007599 (hemostasis)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0031638 (zymogen activation)
Wikipedia Factor_IX

Target Cross References - Protein

canSAR P00740
CGD Hemophilia B; Thrombophilia, X-linked, due to factor IX defect; Warfarin sensitivity
Human Protein Atlas ENSG00000101981
IntAct P00740
Guide to Pharmacology 2364
Open Targets ENSG00000101981
PharmGKB PA27954
Reactome R-HSA-140834 (Extrinsic Pathway of Fibrin Clot Formation.)
R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
R-HSA-159740 (Gamma-carboxylation of protein precursors.)
R-HSA-159763 (Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.)
R-HSA-159782 (Removal of aminoterminal propeptides from gamma-carboxylated proteins.)
UniProt A8K9N4 F2RM36 P00740 Q5FBE1 Q5JYJ8

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000294 (GLA_domain.)
IPR000742 (EGF-like_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR012224 (Pept_S1A_FX.)
IPR013032 (EGF-like_CS.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018097 (EGF_Ca-bd_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00008 (EGF)
PF00089 (Trypsin)
PF00594 (Gla)

Target Cross References - Structure

PDBe 1EDM 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM
CREDO 1EDM 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM
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