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Target Report Card

Target Name and Classification

Target ID CHEMBL2015
Target Type SINGLE PROTEIN
Preferred Name Glutamate (NMDA) receptor subunit zeta 1
Synonyms GRIN1 | GluN1 | Glutamate [NMDA] receptor subunit zeta-1 | Glutamate receptor ionotropic, NMDA 1 | N-methyl-D-aspartate receptor subunit NR1 | NMD-R1 | NMDAR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 1 SINGLE PROTEIN Q05586

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094124 Glutamate [NMDA] receptor PROTEIN COMPLEX GROUP
CHEMBL1907603 Glutamate NMDA receptor; GRIN1/GRIN2B PROTEIN COMPLEX
CHEMBL3038505 Ionotropic glutamate receptor NMDA 1/2D PROTEIN COMPLEX
CHEMBL3038504 Ionotropic glutamate receptor NMDA 1/2C PROTEIN COMPLEX
CHEMBL1907604 Glutamate NMDA receptor; GRIN1/GRIN2A PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176884
Ensembl ENSG00000176884
GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0043005 (neuron projection)
GO:0043083 (synaptic cleft)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0060076 (excitatory synapse)
GO:0097060 (synaptic membrane)
GO:0098839 (postsynaptic density membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005261 (cation channel activity)
GO:0005262 (calcium channel activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0016594 (glycine binding)
GO:0016595 (glutamate binding)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0038023 (signaling receptor activity)
GO:0042165 (neurotransmitter binding)
GO:0044877 (macromolecular complex binding)
GO:1904315 (transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001661 (conditioned taste aversion)
GO:0001964 (startle response)
GO:0001967 (suckling behavior)
GO:0001975 (response to amphetamine)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007420 (brain development)
GO:0007585 (respiratory gaseous exchange)
GO:0007611 (learning or memory)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007616 (long-term memory)
GO:0008306 (associative learning)
GO:0008344 (adult locomotory behavior)
GO:0008355 (olfactory learning)
GO:0008542 (visual learning)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0010646 (regulation of cell communication)
GO:0018964 (propylene metabolic process)
GO:0019233 (sensory perception of pain)
GO:0019722 (calcium-mediated signaling)
GO:0021586 (pons maturation)
GO:0021987 (cerebral cortex development)
GO:0035176 (social behavior)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0042391 (regulation of membrane potential)
GO:0043065 (positive regulation of apoptotic process)
GO:0043278 (response to morphine)
GO:0043523 (regulation of neuron apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043576 (regulation of respiratory gaseous exchange)
GO:0045471 (response to ethanol)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048167 (regulation of synaptic plasticity)
GO:0048168 (regulation of neuronal synaptic plasticity)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048814 (regulation of dendrite morphogenesis)
GO:0050770 (regulation of axonogenesis)
GO:0050905 (neuromuscular process)
GO:0051290 (protein heterotetramerization)
GO:0051963 (regulation of synapse assembly)
GO:0055074 (calcium ion homeostasis)
GO:0060079 (excitatory postsynaptic potential)
GO:0060134 (prepulse inhibition)
GO:0060179 (male mating behavior)
GO:0097553 (calcium ion transmembrane import into cytosol)
GO:0098976 (excitatory chemical synaptic transmission)
GO:1903428 (positive regulation of reactive oxygen species biosynthetic process)
GO:1903539 (protein localization to postsynaptic membrane)
GO:1904646 (cellular response to beta-amyloid)
GO:1905429 (response to glycine)
GO:2000463 (positive regulation of excitatory postsynaptic potential)
GO:2001056 (positive regulation of cysteine-type endopeptidase activity)
Wikipedia GRIN1

Target Cross References - Protein

canSAR Q05586
CGD Mental retardation, autosomal dominant 8
Human Protein Atlas ENSG00000176884
IntAct Q05586
Guide to Pharmacology 455
Open Targets ENSG00000176884
PharmGKB PA28978
Pharos Q05586 (Tclin)
Reactome R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6794361 (Neurexins and neuroligins.)
R-HSA-8849932 (Synaptic adhesion-like molecules.)
UniProt A6NLK7 A6NLR1 C9K0X1 P35437 Q05586 Q12867 Q12868 Q5VSF3 Q5VSF4 Q5VSF5 Q5VSF6 Q5VSF7 Q5VSF8 Q9UPF8 Q9UPF9

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR018882 (CaM-bd_C0_NMDA_rcpt_NR1.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10562 (CaM_bdg_C0)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 2HQW 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA
CREDO 2HQW 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA
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