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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2012
Preferred Name Vitamin K-dependent gamma-carboxylase
Synonyms GC | GGCX | Gamma-glutamyl carboxylase | Peptidyl-glutamate 4-carboxylase | Vitamin K gamma glutamyl carboxylase | Vitamin K-dependent gamma-carboxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Vitamin K-dependent gamma-carboxylase SINGLE PROTEIN P38435

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL712 ANISINDIONE Vitamin K-dependent gamma-carboxylase inhibitor 4 ISBN PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115486
Ensembl ENSG00000115486
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0008488 (gamma-glutamyl carboxylase activity)
GO:0016829 (lyase activity)
GO Biological Process GO:0006464 (cellular protein modification process)
GO:0007596 (blood coagulation)
GO:0017187 (peptidyl-glutamic acid carboxylation)
Wikipedia Gamma-glutamyl_carboxylase

Target Cross References - Protein

canSAR P38435
CGD Vitamin K-dependent clotting factors, combined deficiency of, 1; Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
Human Protein Atlas ENSG00000115486
IntAct P38435
Open Targets ENSG00000115486
PharmGKB PA28660
Reactome R-HSA-159740 (Gamma-carboxylation of protein precursors.)
UniProt B4DMC5 E9PEE1 P38435 Q14415 Q6GU45

Target Cross References - Domain

InterPro IPR007782 (VKG_COase.)
IPR011020 (HTTM.)
IPR011051 (RmlC_Cupin_sf.)
Pfam PF05090 (VKG_Carbox)