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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2008
Target Type SINGLE PROTEIN
Preferred Name Retinoic acid receptor beta
Synonyms HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | Retinoic acid receptor beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group b > nuclear hormone receptor subfamily 1 group b member 2

Target Components

Component Description Relationship Accession
Retinoic acid receptor beta SINGLE PROTEIN P10826

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363069 Retinoic acid receptor PROTEIN FAMILY
CHEMBL3885631 Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta PROTEIN COMPLEX
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000077092
Ensembl ENSG00000077092
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046965 (retinoid X receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001657 (ureteric bud development)
GO:0002068 (glandular epithelial cell development)
GO:0003148 (outflow tract septum morphogenesis)
GO:0003406 (retinal pigment epithelium development)
GO:0003417 (growth plate cartilage development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0021756 (striatum development)
GO:0022008 (neurogenesis)
GO:0031641 (regulation of myelination)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0035264 (multicellular organism growth)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043068 (positive regulation of programmed cell death)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048048 (embryonic eye morphogenesis)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0048566 (embryonic digestive tract development)
GO:0055012 (ventricular cardiac muscle cell differentiation)
GO:0060041 (retina development in camera-type eye)
GO:0060348 (bone development)
GO:0061037 (negative regulation of cartilage development)
Wikipedia Retinoic_acid_receptor_beta

Target Cross References - Protein

canSAR P10826
Human Protein Atlas ENSG00000077092
IntAct P10826
Guide to Pharmacology 591
Open Targets ENSG00000077092
PharmGKB PA34226
Pharos P10826 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
UniProt P10826 P12891 Q00989 Q15298 Q9UN48

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN
CREDO 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN
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