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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2004
Target Type SINGLE PROTEIN
Preferred Name Retinoid X receptor gamma
Synonyms NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 3

Target Components

Component Description Relationship Accession
Retinoic acid receptor RXR-gamma SINGLE PROTEIN P48443

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363070 Retinoid X receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143171
Ensembl ENSG00000143171
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004886 (9-cis retinoic acid receptor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0051289 (protein homotetramerization)
GO:1901522 (positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)
Wikipedia Retinoid_X_receptor_gamma

Target Cross References - Protein

canSAR P48443
Human Protein Atlas ENSG00000143171
IntAct P48443
Guide to Pharmacology 612
Open Targets ENSG00000143171
PharmGKB PA34892
Pharos P48443 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
UniProt A6NIP1 P48443 Q6IBU7

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt/HNF4.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR021780 (Nuc_recep-AF1.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF11825 (Nuc_recep-AF1)

Target Cross References - Structure

PDBe 2GL8
CREDO 2GL8
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