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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2003
Target Type SINGLE PROTEIN
Preferred Name Retinoic acid receptor gamma
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group b > nuclear hormone receptor subfamily 1 group b member 3

Target Components

Component Description Relationship Accession
Retinoic acid receptor gamma SINGLE PROTEIN P13631

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363069 Retinoic acid receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172819
Ensembl ENSG00000172819
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005654 (nucleoplasm)
GO:0005634 (nucleus)
GO:0005667 (transcription factor complex)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0046965 (retinoid X receptor binding)
GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0003430 (growth plate cartilage chondrocyte growth)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0045637 (regulation of myeloid cell differentiation)
GO:0048048 (embryonic eye morphogenesis)
GO:0032526 (response to retinoic acid)
GO:0043066 (negative regulation of apoptotic process)
GO:0031641 (regulation of myelination)
GO:0060324 (face development)
GO:0009952 (anterior/posterior pattern specification)
GO:0010467 (gene expression)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0035264 (multicellular organism growth)
GO:0043068 (positive regulation of programmed cell death)
GO:0060534 (trachea cartilage development)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0003406 (retinal pigment epithelium development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0031076 (embryonic camera-type eye development)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0071300 (cellular response to retinoic acid)
GO:0001843 (neural tube closure)
GO:0002068 (glandular epithelial cell development)
GO:0043065 (positive regulation of apoptotic process)
GO:0008361 (regulation of cell size)
GO:0070384 (Harderian gland development)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060740 (prostate gland epithelium morphogenesis)
Wikipedia Retinoic_acid_receptor_gamma

Target Cross References - Protein

canSAR P13631
Human Protein Atlas ENSG00000172819
IntAct P13631
Guide to Pharmacology 592 (Retinoic acid receptor-Gamma;)
PharmGKB PA34227
UniProt Q52LZ8 Q9BYX8 B7ZAE4 P22932 Q9H1I3 P13631 Q15281 Q9UJ38

Target Cross References - Domain

InterPro IPR001628 (Znf_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001723 (Nuclear_hrmn_rcpt.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1EXA 4LBD 1FCY 2LBD 1FCX 1FD0 3LBD 1EXX 1FCZ
CREDO 1EXA 4LBD 1FCY 2LBD 1FCX 1FD0 3LBD 1EXX 1FCZ
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