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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2003
Target Type SINGLE PROTEIN
Preferred Name Retinoic acid receptor gamma
Synonyms NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | Retinoic acid receptor gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group b > nuclear hormone receptor subfamily 1 group b member 3

Target Components

Component Description Relationship Accession
Retinoic acid receptor gamma SINGLE PROTEIN P13631

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363069 Retinoic acid receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY
CHEMBL3885633 Retinoic acid receptor RXR-alpha/gamma PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105648 PALOVAROTENE Retinoic acid receptor gamma agonist 3 Other PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172819
Ensembl ENSG00000172819
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0046965 (retinoid X receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001843 (neural tube closure)
GO:0002063 (chondrocyte development)
GO:0002068 (glandular epithelial cell development)
GO:0003406 (retinal pigment epithelium development)
GO:0003417 (growth plate cartilage development)
GO:0003430 (growth plate cartilage chondrocyte growth)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008361 (regulation of cell size)
GO:0009952 (anterior/posterior pattern specification)
GO:0010468 (regulation of gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0031076 (embryonic camera-type eye development)
GO:0031641 (regulation of myelination)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0032526 (response to retinoic acid)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0035264 (multicellular organism growth)
GO:0043010 (camera-type eye development)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043068 (positive regulation of programmed cell death)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045596 (negative regulation of cell differentiation)
GO:0045637 (regulation of myeloid cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048048 (embryonic eye morphogenesis)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0048608 (reproductive structure development)
GO:0048732 (gland development)
GO:0060041 (retina development in camera-type eye)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060173 (limb development)
GO:0060324 (face development)
GO:0060348 (bone development)
GO:0060349 (bone morphogenesis)
GO:0060429 (epithelium development)
GO:0060534 (trachea cartilage development)
GO:0060740 (prostate gland epithelium morphogenesis)
GO:0061037 (negative regulation of cartilage development)
GO:0070384 (Harderian gland development)
GO:0071300 (cellular response to retinoic acid)
GO:1990830 (cellular response to leukemia inhibitory factor)
Wikipedia Retinoic_acid_receptor_gamma

Target Cross References - Protein

canSAR P13631
Human Protein Atlas ENSG00000172819
IntAct P13631
Guide to Pharmacology 592
Open Targets ENSG00000172819
PharmGKB PA34227
Pharos P13631 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
UniProt B7Z492 B7Z4F1 B7ZAE4 J3KNP6 P13631 P22932 Q15281 Q52LZ8 Q9BYX8 Q9H1I3 Q9UJ38

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24
CREDO 1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24
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