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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2003
Target Type SINGLE PROTEIN
Preferred Name Retinoic acid receptor gamma
Synonyms NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | Retinoic acid receptor gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group b > nuclear hormone receptor subfamily 1 group b member 3

Target Components

Component Description Relationship Accession
Retinoic acid receptor gamma SINGLE PROTEIN P13631

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363069 Retinoic acid receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1265 ADAPALENE Retinoic acid receptor gamma agonist PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172819
Ensembl ENSG00000172819
GO Cellular Component GO:0005667 (transcription factor complex)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046965 (retinoid X receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0008285 (negative regulation of cell proliferation)
GO:0008361 (regulation of cell size)
GO:0032526 (response to retinoic acid)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0043065 (positive regulation of apoptosis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048048 (embryonic eye morphogenesis)
GO:0060070 (canonical Wnt receptor signaling pathway)
Wikipedia Retinoic_acid_receptor_gamma

Target Cross References - Protein

canSAR P13631
Human Protein Atlas ENSG00000172819
IntAct P13631
Guide to Pharmacology 592 (Retinoic acid receptor-Gamma;)
PharmGKB PA34227
Reactome REACT_71 (Gene Expression.)
UniProt B7ZAE4 P13631 P22932 Q15281 Q52LZ8 Q9BYX8 Q9H1I3 Q9UJ38

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD
CREDO 1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD
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