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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1996
Target Type SINGLE PROTEIN
Preferred Name Granulocyte colony stimulating factor receptor
Synonyms CD_antigen=CD114 | CSF3R | G-CSF receptor | G-CSF-R | GCSFR | Granulocyte colony-stimulating factor receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Granulocyte colony-stimulating factor receptor SINGLE PROTEIN Q99062

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201567 FILGRASTIM Granulocyte colony stimulating factor receptor agonist DailyMed PubMed PubMed
CHEMBL1201568 PEGFILGRASTIM Granulocyte colony stimulating factor receptor agonist DailyMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000119535
Ensembl ENSG00000119535
GO Cellular Component GO:0005576 (extracellular region)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004896 (cytokine receptor activity)
GO Biological Process GO:0006952 (defense response)
GO:0007155 (cell adhesion)
Wikipedia Granulocyte_colony-stimulating_factor_receptor

Target Cross References - Protein

canSAR Q99062
CGD Neutrophilia, hereditary
Human Protein Atlas ENSG00000119535
PharmGKB PA26942

Target Cross References - Domain

InterPro IPR003529 (Hematopoietin_rcpt_gp130_CS.)
IPR003961 (FN_III.)
IPR008957 (Fibronectin_III_dom.)
IPR010457 (IgC2-like_lig-bd.)
IPR013783 (Ig-like_fold.)
Pfam PF00041 (fn3)
PF06328 (Lep_receptor_Ig)

Target Cross References - Structure

PDBe 2D9Q
CREDO 2D9Q
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