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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1995
Preferred Name Prostanoid IP receptor
Synonyms PGI receptor | PGI2 receptor | PRIPR | PTGIR | Prostacyclin receptor | Prostaglandin I2 receptor | Prostanoid IP receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostacyclin receptor SINGLE PROTEIN P43119

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL494 ILOPROST Prostanoid IP receptor agonist 4 DailyMed ISBN
CHEMBL962 EPOPROSTENOL SODIUM Prostanoid IP receptor agonist 4 FDA ISBN
CHEMBL238804 SELEXIPAG Prostanoid IP receptor agonist 4 FDA
CHEMBL1237119 TREPROSTINIL Prostanoid IP receptor agonist 4 PubMed
CHEMBL2107815 TREPROSTINIL DIOLAMINE Prostanoid IP receptor agonist 4 PubMed
CHEMBL3137314 ESUBERAPROST Prostanoid IP receptor agonist 3 Other
CHEMBL3301604 RALINEPAG Prostanoid IP receptor agonist 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160013
Ensembl ENSG00000160013
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0010642 (negative regulation of platelet-derived growth factor receptor signaling pathway)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0032496 (response to lipopolysaccharide)
GO:0043547 (positive regulation of GTPase activity)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
Wikipedia Prostacyclin_receptor

Target Cross References - Protein

canSAR P43119
Human Protein Atlas ENSG00000160013
Guide to Pharmacology 345
Open Targets ENSG00000160013
PharmGKB PA291
Pharos P43119 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-392851 (Prostacyclin signalling through prostacyclin receptor.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt P43119

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000370 (Prostglndn_IP_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)