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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1995
Preferred Name Prostanoid IP receptor
Synonyms PGI receptor | PGI2 receptor | PRIPR | PTGIR | Prostacyclin receptor | Prostaglandin I2 receptor | Prostanoid IP receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostacyclin receptor SINGLE PROTEIN P43119

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL962 EPOPROSTENOL SODIUM Prostanoid IP receptor agonist FDA ISBN
CHEMBL494 ILOPROST Prostanoid IP receptor agonist DailyMed ISBN
CHEMBL1237119 TREPROSTINIL Prostanoid IP receptor agonist PubMed
CHEMBL2107815 TREPROSTINIL DIOLAMINE Prostanoid IP receptor agonist PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160013
Ensembl ENSG00000160013
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004930 (G-protein coupled receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO Biological Process GO:0007187 (G-protein signaling, coupled to cyclic nucleotide second messenger)
GO:0007267 (cell-cell signaling)
GO:0030168 (platelet activation)
Wikipedia Prostacyclin_receptor

Target Cross References - Protein

canSAR P43119
Human Protein Atlas ENSG00000160013
Guide to Pharmacology 345 (IP1)
PharmGKB PA291
Reactome REACT_14797 (Signaling by GPCR.)
REACT_604 (Hemostasis.)
UniProt P43119

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000370 (Prostglndn_IP_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)