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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1994
Target Type SINGLE PROTEIN
Preferred Name Mineralocorticoid receptor
Synonyms MCR | MLR | MR | Mineralocorticoid receptor | NR3C2 | Nuclear receptor subfamily 3 group C member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 2

Target Components

Component Description Relationship Accession
Mineralocorticoid receptor SINGLE PROTEIN P08235

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1393 SPIRONOLACTONE Mineralocorticoid receptor antagonist 4 DailyMed
CHEMBL1428 NIMODIPINE Mineralocorticoid receptor antagonist 4 PubMed
CHEMBL1480 FELODIPINE Mineralocorticoid receptor antagonist 4 PubMed
CHEMBL1509 DROSPIRENONE Mineralocorticoid receptor antagonist 4 DailyMed PubMed
CHEMBL1095097 EPLERENONE Mineralocorticoid receptor antagonist 4 DailyMed
CHEMBL1200542 DESOXYCORTICOSTERONE ACETATE Mineralocorticoid receptor agonist 4 DailyMed PubMed
CHEMBL1200592 DESOXYCORTICOSTERONE PIVALATE Mineralocorticoid receptor agonist 4 DailyMed
CHEMBL1201010 FLUDROCORTISONE ACETATE Mineralocorticoid receptor agonist 4 PubMed
CHEMBL2181927 FINERENONE Mineralocorticoid receptor antagonist 3 PubMed
CHEMBL3545275 LY2623091 Mineralocorticoid receptor antagonist 2 Other Other
CHEMBL3545392 MT-3995 Mineralocorticoid receptor antagonist 2 Other
CHEMBL3545393 XL550 Mineralocorticoid receptor antagonist 2 Other
CHEMBL3545175 PF-03882845 Mineralocorticoid receptor antagonist 1 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151623
Ensembl ENSG00000151623
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0005496 (steroid binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0043401 (steroid hormone mediated signaling pathway)
Wikipedia Mineralocorticoid_receptor

Target Cross References - Protein

canSAR P08235
CGD Pseudohypoaldosteronism type I, autosomal dominant; Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy
Human Protein Atlas ENSG00000151623
IntAct P08235
Guide to Pharmacology 626
Open Targets ENSG00000151623
PharmGKB PA242
Pharos P08235 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt B0ZBF5 B0ZBF7 P08235 Q2NKL1 Q96KQ8 Q96KQ9

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H
CREDO 1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H
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