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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1994
Preferred Name Mineralocorticoid receptor
Synonyms MCR | MLR | MR | Mineralocorticoid receptor | NR3C2 | Nuclear receptor subfamily 3 group C member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 2

Target Components

Component Description Relationship Accession
Mineralocorticoid receptor SINGLE PROTEIN P08235

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1200542 DESOXYCORTICOSTERONE ACETATE Mineralocorticoid receptor agonist DailyMed PubMed
CHEMBL1200592 DESOXYCORTICOSTERONE PIVALATE Mineralocorticoid receptor agonist DailyMed
CHEMBL1509 DROSPIRENONE Mineralocorticoid receptor antagonist DailyMed PubMed
CHEMBL1095097 EPLERENONE Mineralocorticoid receptor antagonist DailyMed
CHEMBL1480 FELODIPINE Mineralocorticoid receptor antagonist PubMed
CHEMBL1201010 FLUDROCORTISONE ACETATE Mineralocorticoid receptor agonist PubMed
CHEMBL1428 NIMODIPINE Mineralocorticoid receptor antagonist PubMed
CHEMBL1393 SPIRONOLACTONE Mineralocorticoid receptor antagonist DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151623
Ensembl ENSG00000151623
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0005496 (steroid binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
Wikipedia Mineralocorticoid_receptor

Target Cross References - Protein

canSAR P08235
CGD Pseudohypoaldosteronism type I, autosomal dominant; Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy
Human Protein Atlas ENSG00000151623
IntAct P08235
Guide to Pharmacology 626 (Mineralocorticoid receptor)
PharmGKB PA242
Reactome REACT_71 (Gene Expression.)
UniProt P08235 Q96KQ8 Q96KQ9

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX
CREDO 1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX