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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1992
Target Type SINGLE PROTEIN
Preferred Name DNA (cytosine-5)-methyltransferase 3A
Synonyms DNA (cytosine-5)-methyltransferase 3A | DNA MTase HsaIIIA | DNA methyltransferase HsaIIIA | DNMT3A | Dnmt3a | M.HsaIIIA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > methyl-lysine/arginine binding protein > pwwp domain
  • epigenetic regulator > writer > dna methyltransferase

Target Components

Component Description Relationship Accession
DNA (cytosine-5)-methyltransferase 3A SINGLE PROTEIN Q9Y6K1

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137291 DNMT3A2/3L complex PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1489 AZACITIDINE DNA (cytosine-5)-methyltransferase 3A inhibitor 4 DailyMed
CHEMBL1201129 DECITABINE DNA (cytosine-5)-methyltransferase 3A inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000119772
Ensembl ENSG00000119772
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000791 (euchromatin)
GO:0000792 (heterochromatin)
GO:0001741 (XY body)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005720 (nuclear heterochromatin)
GO:0005737 (cytoplasm)
GO:0016363 (nuclear matrix)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003886 (DNA (cytosine-5-)-methyltransferase activity)
GO:0005515 (protein binding)
GO:0008168 (methyltransferase activity)
GO:0009008 (DNA-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000278 (mitotic cell cycle)
GO:0006306 (DNA methylation)
GO:0006325 (chromatin organization)
GO:0006346 (methylation-dependent chromatin silencing)
GO:0006349 (regulation of gene expression by genetic imprinting)
GO:0007283 (spermatogenesis)
GO:0007568 (aging)
GO:0009636 (response to toxic substance)
GO:0010212 (response to ionizing radiation)
GO:0010288 (response to lead ion)
GO:0010468 (regulation of gene expression)
GO:0010942 (positive regulation of cell death)
GO:0030182 (neuron differentiation)
GO:0031667 (response to nutrient levels)
GO:0032259 (methylation)
GO:0032355 (response to estradiol)
GO:0032776 (DNA methylation on cytosine)
GO:0033189 (response to vitamin A)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0043045 (DNA methylation involved in embryo development)
GO:0043046 (DNA methylation involved in gamete generation)
GO:0045471 (response to ethanol)
GO:0045814 (negative regulation of gene expression, epigenetic)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071361 (cellular response to ethanol)
GO:0071456 (cellular response to hypoxia)
GO:0090116 (C-5 methylation of cytosine)
GO:0097284 (hepatocyte apoptotic process)
Wikipedia DNMT3A

Target Cross References - Protein

canSAR Q9Y6K1
Human Protein Atlas ENSG00000119772
IntAct Q9Y6K1
Open Targets ENSG00000119772
PharmGKB PA27445
Reactome R-HSA-212300 (PRC2 methylates histones and DNA.)
R-HSA-3214858 (RMTs methylate histone arginines.)
R-HSA-5334118 (DNA methylation.)
UniProt E9PEB8 Q86TE8 Q86XF5 Q8IZV0 Q8WXU9 Q9Y6K1

Target Cross References - Domain

InterPro IPR000313 (PWWP_dom.)
IPR001525 (C5_MeTfrase.)
IPR018117 (C5_DNA_meth_AS.)
IPR025766 (ADD.)
IPR029063 (SAM-dependent_MTases.)
IPR030487 (DNMT3A.)
Pfam PF00855 (PWWP)

Target Cross References - Structure

PDBe 2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T
CREDO 2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T
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