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Target Report Card

Target Name and Classification

Target ID CHEMBL1991
Target Type SINGLE PROTEIN
Preferred Name Inhibitor of nuclear factor kappa B kinase beta subunit
Synonyms I-kappa-B kinase 2 | I-kappa-B-kinase beta | IKBKB | IKK-B | IKK-beta | IKK2 | IKKB | IkBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | NFKBIKB | Nuclear factor NF-kappa-B inhibitor kinase beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group

Target Components

Component Description Relationship Accession
Inhibitor of nuclear factor kappa-B kinase subunit beta SINGLE PROTEIN O14920

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111328 Inhibitor of NF-kappa-B kinase (IKK) PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1762621 BARDOXOLONE METHYL Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 3 PubMed
CHEMBL3544945 SAR-113945 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 2 Other
CHEMBL3545168 IMD-1041 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 2 PubMed
CHEMBL3545089 IMD-0354 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1 PubMed
CHEMBL3545147 IMD-2560 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1 Other PubMed
CHEMBL3545242 AS-602868 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1
CHEMBL3545265 MLN-0415 Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor 1 Other Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104365
Ensembl ENSG00000104365
GO Cellular Component GO:0009898 (cytoplasmic side of plasma membrane)
GO:0005829 (cytosol)
GO:0008385 (IkappaB kinase complex)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0035631 (CD40 receptor complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0042803 (protein homodimerization activity)
GO:0005524 (ATP binding)
GO:0008384 (IkappaB kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0019901 (protein kinase binding)
GO:0097110 (scaffold protein binding)
GO:0004672 (protein kinase activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0010765 (positive regulation of sodium ion transport)
GO:0031175 (neuron projection development)
GO:1903140 (regulation of establishment of endothelial barrier)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0007252 (I-kappaB phosphorylation)
GO:0030866 (cortical actin cytoskeleton organization)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0042325 (regulation of phosphorylation)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0090002 (establishment of protein localization to plasma membrane)
GO:0006468 (protein phosphorylation)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070542 (response to fatty acid)
GO:1903347 (negative regulation of bicellular tight junction assembly)
GO:0001782 (B cell homeostasis)
GO:0006954 (inflammatory response)
GO:0035509 (negative regulation of myosin-light-chain-phosphatase activity)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0003009 (skeletal muscle contraction)
GO:0008284 (positive regulation of cell proliferation)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034166 (toll-like receptor 10 signaling pathway)
GO:0035872 (nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway)
GO:0038123 (toll-like receptor TLR1:TLR2 signaling pathway)
GO:0045087 (innate immune response)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051403 (stress-activated MAPK cascade)
GO:0009615 (response to virus)
GO:0032481 (positive regulation of type I interferon production)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038124 (toll-like receptor TLR6:TLR2 signaling pathway)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0007166 (cell surface receptor signaling pathway)
GO:0009636 (response to toxic substance)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0042501 (serine phosphorylation of STAT protein)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:2001259 (positive regulation of cation channel activity)
GO:0002224 (toll-like receptor signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034146 (toll-like receptor 5 signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0071356 (cellular response to tumor necrosis factor)
GO:1901216 (positive regulation of neuron death)
Wikipedia IKK2

Target Cross References - Protein

canSAR O14920
Human Protein Atlas ENSG00000104365
IntAct O14920
Guide to Pharmacology 2039 (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta)
PharmGKB PA29776
UniProt O75327 B4DZ30 O14920

Target Cross References - Domain

InterPro IPR008271 (Ser/Thr_kinase_AS.)
IPR022007 (IKKbetaNEMObind.)
IPR000719 (Prot_kinase_dom.)
IPR029071 (Ubiquitin-rel_dom.)
IPR000626 (Ubiquitin_dom.)
IPR011009 (Kinase-like_dom.)
Pfam PF12179 (IKKbetaNEMObind)
PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3BRT 3BRV 4E3C 4KIK
CREDO 3BRT 3BRV 4E3C 4KIK
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