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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1991
Target Type SINGLE PROTEIN
Preferred Name Inhibitor of nuclear factor kappa B kinase beta subunit
Synonyms I-kappa-B kinase 2 | I-kappa-B-kinase beta | IKBKB | IKK-B | IKK-beta | IKK2 | IKKB | IkBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | NFKBIKB | Nuclear factor NF-kappa-B inhibitor kinase beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group

Target Components

Component Description Relationship Accession
Inhibitor of nuclear factor kappa-B kinase subunit beta SINGLE PROTEIN O14920

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111328 Inhibitor of NF-kappa-B kinase (IKK) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104365
Ensembl ENSG00000104365
GO Cellular Component GO:0005829 (cytosol)
GO:0009898 (internal side of plasma membrane)
GO:0035631 (CD40 receptor complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005524 (ATP binding)
GO:0008384 (IkappaB kinase activity)
GO:0016563 (transcription activator activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006916 (anti-apoptosis)
GO:0008063 (Toll signaling pathway)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0045087 (innate immune response)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
Wikipedia IKK2

Target Cross References - Protein

canSAR O14920
Human Protein Atlas ENSG00000104365
IntAct O14920
Guide to Pharmacology 2039 (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta)
PharmGKB PA29776
Reactome REACT_11061 (Signalling by NGF.)
REACT_6900 (Signaling in Immune system.)
UniProt B4DZ30 O14920 O75327

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR019955 (Ubiquitin_supergroup.)
IPR022007 (IKKbetaNEMObind.)
Pfam PF00069 (Pkinase)
PF12179 (IKKbetaNEMObind)

Target Cross References - Structure

PDBe 3BRT 3BRV
CREDO 3BRT 3BRV
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