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Target Report Card

Target Name and Classification

Target ID CHEMBL1980
Target Type SINGLE PROTEIN
Preferred Name Sodium channel protein type V alpha subunit
Synonyms HH1 | SCN5A | Sodium channel protein cardiac muscle subunit alpha | Sodium channel protein type 5 subunit alpha | Sodium channel protein type V subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 5 subunit alpha SINGLE PROTEIN Q14524

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1404 RANOLAZINE Sodium channel protein type V alpha subunit blocker 4 PubMed
CHEMBL1200612 DIBUCAINE HYDROCHLORIDE Sodium channel protein type V alpha subunit blocker 4 PubMed PubMed
CHEMBL1200822 FLECAINIDE ACETATE Sodium channel protein type V alpha subunit blocker 4 PubMed
CHEMBL3545040 AZD7009 Sodium channel protein type V alpha subunit blocker 2 PubMed
CHEMBL3545169 AZD1305 Sodium channel protein type V alpha subunit blocker 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000183873
Ensembl ENSG00000183873
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005622 (intracellular)
GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0009986 (cell surface)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016328 (lateral plasma membrane)
GO:0030018 (Z disc)
GO:0030315 (T-tubule)
GO:0042383 (sarcolemma)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0017134 (fibroblast growth factor binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0030506 (ankyrin binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0044325 (ion channel binding)
GO:0050998 (nitric-oxide synthase binding)
GO:0086006 (voltage-gated sodium channel activity involved in cardiac muscle cell action potential)
GO:0086060 (voltage-gated sodium channel activity involved in AV node cell action potential)
GO:0086061 (voltage-gated sodium channel activity involved in bundle of His cell action potential)
GO:0086062 (voltage-gated sodium channel activity involved in Purkinje myocyte action potential)
GO:0086063 (voltage-gated sodium channel activity involved in SA node cell action potential)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0002027 (regulation of heart rate)
GO:0003231 (cardiac ventricle development)
GO:0003360 (brainstem development)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0010765 (positive regulation of sodium ion transport)
GO:0014894 (response to denervation involved in regulation of muscle adaptation)
GO:0019228 (neuronal action potential)
GO:0021537 (telencephalon development)
GO:0021549 (cerebellum development)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0045760 (positive regulation of action potential)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0051899 (membrane depolarization)
GO:0055085 (transmembrane transport)
GO:0060048 (cardiac muscle contraction)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060307 (regulation of ventricular cardiac muscle cell membrane repolarization)
GO:0060371 (regulation of atrial cardiac muscle cell membrane depolarization)
GO:0060372 (regulation of atrial cardiac muscle cell membrane repolarization)
GO:0060373 (regulation of ventricular cardiac muscle cell membrane depolarization)
GO:0061337 (cardiac conduction)
GO:0071277 (cellular response to calcium ion)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086004 (regulation of cardiac muscle cell contraction)
GO:0086005 (ventricular cardiac muscle cell action potential)
GO:0086010 (membrane depolarization during action potential)
GO:0086012 (membrane depolarization during cardiac muscle cell action potential)
GO:0086015 (SA node cell action potential)
GO:0086016 (AV node cell action potential)
GO:0086043 (bundle of His cell action potential)
GO:0086045 (membrane depolarization during AV node cell action potential)
GO:0086046 (membrane depolarization during SA node cell action potential)
GO:0086047 (membrane depolarization during Purkinje myocyte cell action potential)
GO:0086048 (membrane depolarization during bundle of His cell action potential)
GO:0086067 (AV node cell to bundle of His cell communication)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:1902305 (regulation of sodium ion transmembrane transport)
Wikipedia Nav1.5

Target Cross References - Protein

canSAR Q14524
CGD Atrial fibrillation, familial 10; Long QT syndrome 3; Idiopathic ventricular fibrillation; Heart block, progressive, type IA; Heart block, nonprogressive; Sick sinus syndrome 1, autosomal recessive; Cardiomyopathy, dilated, 1E; Brugada syndrome 1
Human Protein Atlas ENSG00000183873
IntAct Q14524
Guide to Pharmacology 582
Open Targets ENSG00000183873
PharmGKB PA304
Pharos Q14524 (Tclin)
Reactome R-HSA-445095 (Interaction between L1 and Ankyrins.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
UniProt A5H1P8 A6N922 A6N923 B2RTU0 E7ET19 E9PEF3 E9PEK2 E9PFW7 Q14524 Q59H93 Q75RX9 Q75RY0 Q86UR3 Q8IZC9 Q96J69

Target Cross References - Domain

InterPro IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR008053 (Na_channel_a5su.)
IPR010526 (Na_trans_assoc.)
IPR024583 (Na_trans_cytopl.)
IPR027359 (Channel_four-helix_dom.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)
PF11933 (Na_trans_cytopl)

Target Cross References - Structure

PDBe 4DCK 4DJC 4JQ0 4OVN
CREDO 4DCK 4DJC 4JQ0 4OVN
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