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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1978
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 19A1
Synonyms ARO1 | Aromatase | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Estrogen synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 19 > cytochrome p450 family 19a > cytochrome p450 19a1

Target Components

Component Description Relationship Accession
Aromatase SINGLE PROTEIN P11511

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL488 AMINOGLUTETHIMIDE Cytochrome P450 19A1 inhibitor 4 FDA
CHEMBL1399 ANASTROZOLE Cytochrome P450 19A1 inhibitor 4 DailyMed
CHEMBL1444 LETROZOLE Cytochrome P450 19A1 inhibitor 4 DailyMed
CHEMBL1571 TESTOLACTONE Cytochrome P450 19A1 inhibitor 4 FDA
CHEMBL1200374 EXEMESTANE Cytochrome P450 19A1 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137869
Ensembl ENSG00000137869
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008395 (steroid hydroxylase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0002677 (negative regulation of chronic inflammatory response)
GO:0006694 (steroid biosynthetic process)
GO:0006703 (estrogen biosynthetic process)
GO:0008209 (androgen metabolic process)
GO:0010760 (negative regulation of macrophage chemotaxis)
GO:0016125 (sterol metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0060736 (prostate gland growth)
Wikipedia Aromatase

Target Cross References - Protein

canSAR P11511
CGD Aromatase deficiency
Human Protein Atlas ENSG00000137869
IntAct P11511
Guide to Pharmacology 1362
Open Targets ENSG00000137869
PharmGKB PA27091
Reactome R-HSA-193144 (Estrogen biosynthesis.)
R-HSA-211976 (Endogenous sterols.)
UniProt P11511 Q16731 Q3B764 Q58FA0 Q8IYJ7

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8
CREDO 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8
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