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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1976
Target Type SINGLE PROTEIN
Preferred Name Growth hormone receptor
Synonyms GH receptor | GH-binding protein | GHBP | GHR | Growth hormone receptor | Growth hormone-binding protein | Serum-binding protein | Somatotropin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Growth hormone receptor SINGLE PROTEIN P10912

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201515 PEGVISOMANT Growth hormone receptor antagonist DailyMed
CHEMBL1201620 SOMATREM Growth hormone receptor agonist PubMed
CHEMBL1201621 SOMATROPIN Growth hormone receptor agonist DailyMed ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112964
Ensembl ENSG00000112964
GO Cellular Component GO:0005615 (extracellular space)
GO:0005887 (integral to plasma membrane)
GO:0009986 (cell surface)
GO:0070195 (growth hormone receptor complex)
GO Molecular Function GO:0017046 (peptide hormone binding)
GO:0019838 (growth factor binding)
GO:0019901 (protein kinase binding)
GO:0042803 (protein homodimerization activity)
GO:0070064 (proline-rich region binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0000255 (allantoin metabolic process)
GO:0006101 (citrate metabolic process)
GO:0006103 (2-oxoglutarate metabolic process)
GO:0006105 (succinate metabolic process)
GO:0006107 (oxaloacetate metabolic process)
GO:0006549 (isoleucine metabolic process)
GO:0006573 (valine metabolic process)
GO:0006600 (creatine metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006897 (endocytosis)
GO:0007259 (JAK-STAT cascade)
GO:0019530 (taurine metabolic process)
GO:0031623 (receptor internalization)
GO:0032355 (response to estradiol stimulus)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0042523 (positive regulation of tyrosine phosphorylation of Stat5 protein)
GO:0042977 (activation of JAK2 kinase activity)
GO:0044236 (multicellular organismal metabolic process)
GO:0046449 (creatinine metabolic process)
GO:0046898 (response to cycloheximide)
GO:0048009 (insulin-like growth factor receptor signaling pathway)
GO:0060396 (growth hormone receptor signaling pathway)
Wikipedia Growth_hormone_receptor

Target Cross References - Protein

canSAR P10912
CGD Growth hormone insensitivity syndrome (Laron syndrome)
Human Protein Atlas ENSG00000112964
IntAct P10912
Guide to Pharmacology 1720 (Growth hormone receptor)
PharmGKB PA28674
UniProt P10912 Q9HCX2

Target Cross References - Domain

InterPro IPR003528 (Long_hematopoietin_rcpt_CS.)
IPR003961 (FN_III.)
IPR008957 (Fibronectin_III_dom.)
IPR013783 (Ig-like_fold.)
IPR015152 (Growth/epo_recpt_lig-bind.)
Pfam PF00041 (fn3)
PF09067 (EpoR_lig-bind)

Target Cross References - Structure

PDBe 1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
CREDO 1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
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