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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1976
Target Type SINGLE PROTEIN
Preferred Name Growth hormone receptor
Synonyms GH receptor | GH-binding protein | GHBP | GHR | Growth hormone receptor | Growth hormone-binding protein | Serum-binding protein | Somatotropin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Growth hormone receptor SINGLE PROTEIN P10912

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201620 SOMATREM Growth hormone receptor agonist 4 PubMed
CHEMBL1201515 PEGVISOMANT Growth hormone receptor antagonist 4 DailyMed
CHEMBL1201621 SOMATROPIN Growth hormone receptor agonist 4 DailyMed ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112964
Ensembl ENSG00000112964
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0070195 (growth hormone receptor complex)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0043235 (receptor complex)
GO:0005576 (extracellular region)
GO:0016021 (integral component of membrane)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0019838 (growth factor binding)
GO:0004896 (cytokine receptor activity)
GO:0042803 (protein homodimerization activity)
GO:0070064 (proline-rich region binding)
GO:0019901 (protein kinase binding)
GO:0017046 (peptide hormone binding)
GO Biological Process GO:0006631 (fatty acid metabolic process)
GO:0019530 (taurine metabolic process)
GO:0040014 (regulation of multicellular organism growth)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0006549 (isoleucine metabolic process)
GO:0006103 (2-oxoglutarate metabolic process)
GO:0006105 (succinate metabolic process)
GO:0006107 (oxaloacetate metabolic process)
GO:0032870 (cellular response to hormone stimulus)
GO:0044236 (multicellular organismal metabolic process)
GO:0006600 (creatine metabolic process)
GO:0031623 (receptor internalization)
GO:0032355 (response to estradiol)
GO:0042523 (positive regulation of tyrosine phosphorylation of Stat5 protein)
GO:0042977 (activation of JAK2 kinase activity)
GO:0048009 (insulin-like growth factor receptor signaling pathway)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0006101 (citrate metabolic process)
GO:0006573 (valine metabolic process)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0046449 (creatinine metabolic process)
GO:0060396 (growth hormone receptor signaling pathway)
GO:0000187 (activation of MAPK activity)
GO:0000255 (allantoin metabolic process)
GO:0007259 (JAK-STAT cascade)
GO:0006897 (endocytosis)
GO:0046898 (response to cycloheximide)
Wikipedia Growth_hormone_receptor

Target Cross References - Protein

canSAR P10912
CGD Growth hormone insensitivity syndrome (Laron syndrome)
Human Protein Atlas ENSG00000112964
IntAct P10912
Guide to Pharmacology 1720 (Growth hormone receptor)
PharmGKB PA28674
UniProt P10912 Q9HCX2

Target Cross References - Domain

InterPro IPR003528 (Long_hematopoietin_rcpt_CS.)
IPR003961 (FN3_dom.)
IPR015152 (Growth/epo_recpt_lig-bind.)
IPR025871 (GHBP.)
IPR013783 (Ig-like_fold.)
Pfam PF00041 (fn3)
PF12772 (GHBP)
PF09067 (EpoR_lig-bind)

Target Cross References - Structure

PDBe 1AXI 1HWH 1A22 1HWG 2AEW 1KF9 3HHR
CREDO 1AXI 1HWH 1A22 1HWG 2AEW 1KF9 3HHR
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