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Target Report Card

Target Name and Classification

Target ID CHEMBL1975
Preferred Name T-cell surface glycoprotein CD3 epsilon chain
Synonyms CD3E | CD_antigen=CD3e | T-cell surface antigen T3/Leu-4 epsilon chain | T-cell surface glycoprotein CD3 epsilon chain | T3E
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
T-cell surface glycoprotein CD3 epsilon chain SINGLE PROTEIN P07766

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364168 T cell surface glycoprotein CD3 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108581 CATUMAXOMAB T-cell surface glycoprotein CD3 epsilon chain cross-linking agent 4 Other PubMed PubMed
CHEMBL1743053 OTELIXIZUMAB T-cell surface glycoprotein CD3 epsilon chain binding agent 3 PubMed
CHEMBL1743078 TEPLIZUMAB T-cell surface glycoprotein CD3 epsilon chain other 3 PubMed PubMed
CHEMBL2108811 VISILIZUMAB T-cell surface glycoprotein CD3 epsilon chain inhibitor 3 PubMed
CHEMBL2109253 HOKT3 T-cell surface glycoprotein CD3 epsilon chain inhibitor 3 PubMed
CHEMBL2108029 ERTUMAXOMAB T-cell surface glycoprotein CD3 epsilon chain other 2 PubMed
CHEMBL2109372 MEDI-565 T-cell surface glycoprotein CD3 epsilon chain cross-linking agent 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198851
Ensembl ENSG00000198851
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042101 (T cell receptor complex)
GO:0042105 (alpha-beta T cell receptor complex)
GO:0043197 (dendritic spine)
GO:0044297 (cell body)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005057 (receptor signaling protein activity)
GO:0005515 (protein binding)
GO:0017124 (SH3 domain binding)
GO:0019901 (protein kinase binding)
GO:0030159 (receptor signaling complex scaffold activity)
GO:0042608 (T cell receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002669 (positive regulation of T cell anergy)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007172 (signal complex assembly)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007584 (response to nutrient)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0016358 (dendrite development)
GO:0021549 (cerebellum development)
GO:0031295 (T cell costimulation)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0033077 (T cell differentiation in thymus)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042110 (T cell activation)
GO:0042981 (regulation of apoptotic process)
GO:0045060 (negative thymic T cell selection)
GO:0045086 (positive regulation of interleukin-2 biosynthetic process)
GO:0045879 (negative regulation of smoothened signaling pathway)
GO:0046641 (positive regulation of alpha-beta T cell proliferation)
GO:0046649 (lymphocyte activation)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050776 (regulation of immune response)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050852 (T cell receptor signaling pathway)
GO:0050870 (positive regulation of T cell activation)
GO:0051260 (protein homooligomerization)
GO:0065003 (protein-containing complex assembly)
GO:0097190 (apoptotic signaling pathway)
Wikipedia T-cell_surface_glycoprotein_CD3_epsilon_chain

Target Cross References - Protein

canSAR P07766
CGD Severe combined immunodeficiency, autosomal recessive, T-cell negative, B-cell positive, NK cell positive
Human Protein Atlas ENSG00000198851
IntAct P07766
Guide to Pharmacology 2742
Open Targets ENSG00000198851
PharmGKB PA26216
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-HSA-202430 (Translocation of ZAP-70 to Immunological synapse.)
R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-389948 (PD-1 signaling.)
UniProt A8K997 P07766

Target Cross References - Domain

InterPro IPR003110 (Phos_immunorcpt_sig_ITAM.)
IPR003598 (Ig_sub2.)
IPR013783 (Ig-like_fold.)
IPR015484 (CD3_esu/gsu/dsu.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF02189 (ITAM)

Target Cross References - Structure

PDBe 1A81 1SY6 1XIW