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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1973
Target Type SINGLE PROTEIN
Preferred Name Tyrosinase
Synonyms LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | Tumor rejection antigen AB | Tyrosinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Tyrosinase SINGLE PROTEIN P14679

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL544 MEQUINOL Tyrosinase inhibitor 4 FDA
CHEMBL1388 MONOBENZONE Tyrosinase inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000077498
Ensembl ENSG00000077498
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005798 (Golgi-associated vesicle)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0033162 (melanosome membrane)
GO:0042470 (melanosome)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004503 (monophenol monooxygenase activity)
GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006583 (melanin biosynthetic process from tyrosine)
GO:0006726 (eye pigment biosynthetic process)
GO:0007601 (visual perception)
GO:0008152 (metabolic process)
GO:0008283 (cell proliferation)
GO:0009411 (response to UV)
GO:0033280 (response to vitamin D)
GO:0042438 (melanin biosynthetic process)
GO:0043473 (pigmentation)
GO:0048538 (thymus development)
GO:0051591 (response to cAMP)
GO:0055114 (oxidation-reduction process)
Wikipedia Tyrosinase

Target Cross References - Protein

canSAR P14679
CGD Albinism, oculocutaneous, type IA; Albinism, oculocutaneous, type IB
Human Protein Atlas ENSG00000077498
Open Targets ENSG00000077498
PharmGKB PA37095
Reactome R-HSA-5662702 (Melanin biosynthesis.)
UniProt P14679 Q15675 Q15676 Q15680 Q8TAK4 Q9BYY0 Q9BZX1

Target Cross References - Domain

InterPro IPR002227 (Tyrosinase_Cu-bd.)
IPR008922 (Unchr_di-copper_centre.)
Pfam PF00264 (Tyrosinase)
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