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Target Report Card

Target Name and Classification

Target ID CHEMBL1969
Target Type SINGLE PROTEIN
Preferred Name Tyrosine 3-hydroxylase
Synonyms TH | TH | TYH | Tyrosine 3-hydroxylase | Tyrosine 3-monooxygenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Tyrosine 3-monooxygenase SINGLE PROTEIN P07101

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200862 METYROSINE Tyrosine 3-hydroxylase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180176
Ensembl ENSG00000180176
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0008021 (synaptic vesicle)
GO:0009898 (cytoplasmic side of plasma membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0033162 (melanosome membrane)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043204 (perikaryon)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004511 (tyrosine 3-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0008198 (ferrous iron binding)
GO:0008199 (ferric iron binding)
GO:0016491 (oxidoreductase activity)
GO:0016597 (amino acid binding)
GO:0016714 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0034617 (tetrahydrobiopterin binding)
GO:0035240 (dopamine binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0003007 (heart morphogenesis)
GO:0006585 (dopamine biosynthetic process from tyrosine)
GO:0006631 (fatty acid metabolic process)
GO:0006665 (sphingolipid metabolic process)
GO:0007507 (heart development)
GO:0007601 (visual perception)
GO:0007605 (sensory perception of sound)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007617 (mating behavior)
GO:0007626 (locomotory behavior)
GO:0008016 (regulation of heart contraction)
GO:0009072 (aromatic amino acid family metabolic process)
GO:0009414 (response to water deprivation)
GO:0009416 (response to light stimulus)
GO:0009635 (response to herbicide)
GO:0009651 (response to salt stress)
GO:0009653 (anatomical structure morphogenesis)
GO:0009887 (organ morphogenesis)
GO:0010038 (response to metal ion)
GO:0010043 (response to zinc ion)
GO:0010259 (multicellular organism aging)
GO:0014070 (response to organic cyclic compound)
GO:0014823 (response to activity)
GO:0015842 (aminergic neurotransmitter loading into synaptic vesicle)
GO:0016137 (glycoside metabolic process)
GO:0017085 (response to insecticide)
GO:0018963 (phthalate metabolic process)
GO:0021987 (cerebral cortex development)
GO:0031667 (response to nutrient levels)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0033076 (isoquinoline alkaloid metabolic process)
GO:0035094 (response to nicotine)
GO:0035176 (social behavior)
GO:0035690 (cellular response to drug)
GO:0035900 (response to isolation stress)
GO:0035902 (response to immobilization stress)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042214 (terpene metabolic process)
GO:0042416 (dopamine biosynthetic process)
GO:0042418 (epinephrine biosynthetic process)
GO:0042421 (norepinephrine biosynthetic process)
GO:0042423 (catecholamine biosynthetic process)
GO:0042462 (eye photoreceptor cell development)
GO:0042493 (response to drug)
GO:0042745 (circadian sleep/wake cycle)
GO:0042755 (eating behavior)
GO:0043434 (response to peptide hormone)
GO:0043473 (pigmentation)
GO:0045471 (response to ethanol)
GO:0045472 (response to ether)
GO:0046684 (response to pyrethroid)
GO:0048545 (response to steroid hormone)
GO:0048596 (embryonic camera-type eye morphogenesis)
GO:0050890 (cognition)
GO:0051412 (response to corticosterone)
GO:0051602 (response to electrical stimulus)
GO:0052314 (phytoalexin metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0070848 (response to growth factor)
GO:0071287 (cellular response to manganese ion)
GO:0071312 (cellular response to alkaloid)
GO:0071316 (cellular response to nicotine)
GO:0071333 (cellular response to glucose stimulus)
GO:0071363 (cellular response to growth factor stimulus)
Wikipedia Tyrosine_hydroxylase

Target Cross References - Protein

canSAR P07101
CGD Segawa syndrome, autosomal recessive
Human Protein Atlas ENSG00000180176
IntAct P07101
Open Targets ENSG00000180176
PharmGKB PA351
Reactome R-HSA-209905 (Catecholamine biosynthesis.)
UniProt B7ZL70 B7ZL73 P07101 Q0PWM2 Q0PWM3 Q15585 Q15588 Q15589 Q2M3B4

Target Cross References - Domain

InterPro IPR001273 (ArAA_hydroxylase.)
IPR005962 (Tyr_3_mOase.)
IPR018301 (ArAA_hydroxylase_Fe/CU_BS.)
IPR019773 (Tyrosine_3-monooxygenase-like.)
IPR019774 (Aromatic-AA_hydroxylase_C.)
IPR021164 (Tyrosine_hydroxylase_CS.)
Pfam PF00351 (Biopterin_H)
PF12549 (TOH_N)

Target Cross References - Structure

PDBe 2XSN 4J6S
CREDO 2XSN 4J6S
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