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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1962
Preferred Name GABA receptor alpha-1 subunit
Synonyms GABA(A) receptor subunit alpha-1 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-1 SINGLE PROTEIN P14867

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907597 GABA-A receptor; GABA-A site (alpha1/beta2 interface) PROTEIN COMPLEX
CHEMBL2111392 GABA A receptor alpha-1/beta-1/gamma-2 PROTEIN COMPLEX
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL2094121 GABA-A receptor; alpha-1/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL2095172 GABA-A receptor; alpha-1/beta-2/gamma-2 PROTEIN COMPLEX
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2109243 GABA-A receptor; benzodiazepine site PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000022355
Ensembl ENSG00000022355
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0030054 (cell junction)
GO:0034707 (chloride channel complex)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004890 (GABA-A receptor activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO Biological Process GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (synaptic transmission)
Wikipedia Gamma-aminobutyric_acid_receptor_subunit_alpha-1

Target Cross References - Protein

canSAR P14867
CGD Epilepsy, juvenile myoclonic, susceptibility to, 5; Epilepsy, childhood absence, susceptibility to, 4
Human Protein Atlas ENSG00000022355
Guide to Pharmacology 404 (Alpha;1)
PharmGKB PA28489
Reactome REACT_13685 (Synaptic Transmission.)
REACT_15518 (Transmembrane transport of small molecules.)
UniProt D3DQK6 P14867 Q8N629

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005431 (GABBAa1_rcpt.)
IPR006028 (GABAA_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)