ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1959
Target Type SINGLE PROTEIN
Preferred Name Interleukin-1 receptor
Synonyms CD121 antigen-like family member A | CD_antigen=CD121a | IL-1R-1 | IL-1R-alpha | IL-1RT-1 | IL-1RT1 | IL1R | IL1R1 | IL1RA | IL1RT1 | Interleukin-1 receptor alpha | Interleukin-1 receptor type 1 | Interleukin-1 receptor type 1, membrane form | Interleukin-1 receptor type 1, soluble form | Interleukin-1 receptor type I | mIL-1R1 | mIL-1RI | p80 | sIL-1R1 | sIL-1RI
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Interleukin-1 receptor type 1 SINGLE PROTEIN P14778

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201570 ANAKINRA Interleukin-1 receptor antagonist DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115594
Ensembl ENSG00000115594
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004909 (interleukin-1, Type I, activating receptor activity)
GO:0005161 (platelet-derived growth factor receptor binding)
GO Biological Process GO:0045087 (innate immune response)
Wikipedia Interleukin_1_receptor,_type_I

Target Cross References - Protein

canSAR P14778
Human Protein Atlas ENSG00000115594
IntAct P14778
Guide to Pharmacology 1734 (Interleukin 1 receptor, type I)
PharmGKB PA29809
Reactome REACT_6900 (Signaling in Immune system.)
UniProt P14778 Q587I7

Target Cross References - Domain

InterPro IPR000157 (Toll-Interleukin_rcpt.)
IPR003599 (Ig_sub.)
IPR004074 (IL1_rcpt_I/II.)
IPR004075 (IL1_rcpt_1.)
IPR004076 (IL1R_rcpt.)
IPR007110 (Ig-like.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR015621 (IL1-receptor.)
Pfam PF01582 (TIR)
PF07679 (I-set)

Target Cross References - Structure

PDBe 1G0Y 1IRA 1ITB
CREDO 1G0Y 1IRA 1ITB
spacer
spacer