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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1959
Target Type SINGLE PROTEIN
Preferred Name Interleukin-1 receptor
Synonyms CD121 antigen-like family member A | CD_antigen=CD121a | IL-1R-1 | IL-1R-alpha | IL-1RT-1 | IL-1RT1 | IL1R | IL1R1 | IL1RA | IL1RT1 | Interleukin-1 receptor alpha | Interleukin-1 receptor type 1 | Interleukin-1 receptor type 1, membrane form | Interleukin-1 receptor type 1, soluble form | Interleukin-1 receptor type I | mIL-1R1 | mIL-1RI | p80 | sIL-1R1 | sIL-1RI
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Interleukin-1 receptor type 1 SINGLE PROTEIN P14778

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201570 ANAKINRA Interleukin-1 receptor antagonist 4 DailyMed
CHEMBL2109458 AMG-108 Interleukin-1 receptor antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115594
Ensembl ENSG00000115594
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0043234 (protein complex)
GO Molecular Function GO:0002020 (protease binding)
GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004908 (interleukin-1 receptor activity)
GO:0004909 (interleukin-1, Type I, activating receptor activity)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0005515 (protein binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO Biological Process GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0009314 (response to radiation)
GO:0010286 (heat acclimation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030728 (ovulation)
GO:0050727 (regulation of inflammatory response)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070555 (response to interleukin-1)
GO:0070849 (response to epidermal growth factor)
GO:0071333 (cellular response to glucose stimulus)
GO:0071559 (response to transforming growth factor beta)
GO:0071731 (response to nitric oxide)
Wikipedia Interleukin_1_receptor,_type_I

Target Cross References - Protein

canSAR P14778
Human Protein Atlas ENSG00000115594
IntAct P14778
Guide to Pharmacology 1734
Open Targets ENSG00000115594
PharmGKB PA29809
Reactome R-HSA-446652 (Interleukin-1 signaling.)
R-HSA-6783783 (Interleukin-10 signaling.)
UniProt P14778 Q587I7

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR003599 (Ig_sub.)
IPR004074 (IL-1_rcpt_I/II-typ.)
IPR004076 (IL-1_rcpt_I-typ.)
IPR007110 (Ig-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR015621 (IL-1_rcpt_fam.)
Pfam PF01582 (TIR)
PF07679 (I-set)
PF13895 (Ig_2)

Target Cross References - Structure

PDBe 1G0Y 1IRA 1ITB 4DEP 4GAF
CREDO 1G0Y 1IRA 1ITB 4DEP 4GAF
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