ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1957
Target Type SINGLE PROTEIN
Preferred Name Insulin-like growth factor I receptor
Synonyms CD_antigen=CD221 | IGF-I receptor | IGF1R | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor 1 receptor | Insulin-like growth factor I receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase insr family

Target Components

Component Description Relationship Accession
Insulin-like growth factor 1 receptor SINGLE PROTEIN P08069

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201717 MECASERMIN RINFABATE Insulin-like growth factor I receptor agonist 4 DailyMed
CHEMBL1201716 MECASERMIN Insulin-like growth factor I receptor agonist 4 DailyMed
CHEMBL1091644 LINSITINIB Insulin-like growth factor I receptor inhibitor 3 PubMed PubMed PubMed
CHEMBL1743019 FIGITUMUMAB Insulin-like growth factor I receptor antagonist 3 PubMed
CHEMBL1743024 GANITUMAB Insulin-like growth factor I receptor antagonist 3 PubMed
CHEMBL283120 PICROPODOPHYLLOTOXIN Insulin-like growth factor I receptor inhibitor 2 PubMed PubMed
CHEMBL575448 BMS-754807 Insulin-like growth factor I receptor inhibitor 2 PubMed PubMed
CHEMBL1743001 CIXUTUMUMAB Insulin-like growth factor I receptor antagonist 2 PMC
CHEMBL1743006 DALOTUZUMAB Insulin-like growth factor I receptor antagonist 2
CHEMBL1743064 ROBATUMUMAB Insulin-like growth factor I receptor antagonist 2
CHEMBL1743079 TEPROTUMUMAB Insulin-like growth factor I receptor antagonist 2 Other PubMed PubMed
CHEMBL2109357 AVE-1642 Insulin-like growth factor I receptor antagonist 2 PubMed PubMed
CHEMBL3545025 INSM-18 Insulin-like growth factor I receptor inhibitor 2 PubMed PubMed
CHEMBL3545156 KW-2450 Insulin-like growth factor I receptor inhibitor 2 DOI
CHEMBL551064 AEW-541 Insulin-like growth factor I receptor inhibitor 1 PubMed PubMed
CHEMBL3545004 PL-225B Insulin-like growth factor I receptor inhibitor 1 ClinicalTrials Other
CHEMBL3545085 XL-228 Insulin-like growth factor I receptor inhibitor 1 DOI Other PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140443
Ensembl ENSG00000140443
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0035867 (alphav-beta3 integrin-IGF-1-IGF1R complex)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005010 (insulin-like growth factor-activated receptor activity)
GO:0005158 (insulin receptor binding)
GO:0005515 (protein binding)
GO:0005520 (insulin-like growth factor binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031994 (insulin-like growth factor I binding)
GO:0042802 (identical protein binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0043559 (insulin binding)
GO:0043560 (insulin receptor substrate binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0030335 (positive regulation of cell migration)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0045740 (positive regulation of DNA replication)
GO:0046328 (regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0048009 (insulin-like growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0051262 (protein tetramerization)
GO:0051389 (inactivation of MAPKK activity)
Wikipedia Insulin-like_growth_factor_1_receptor

Target Cross References - Protein

canSAR P08069
CGD Insulin-like growth factor I, resistance to
Human Protein Atlas ENSG00000140443
IntAct P08069
Guide to Pharmacology 1801
Open Targets ENSG00000140443
PharmGKB PA29698
Pharos P08069 (Tclin)
Reactome R-HSA-2404192 (Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).)
R-HSA-2428928 (IRS-related events triggered by IGF1R.)
R-HSA-2428933 (SHC-related events triggered by IGF1R.)
UniProt B1B5Y2 P08069 Q14CV2 Q9UCC0

Target Cross References - Domain

InterPro IPR000494 (Rcpt_L-dom.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR003961 (FN3_dom.)
IPR006211 (Furin-like_Cys-rich_dom.)
IPR006212 (Furin_repeat.)
IPR008266 (Tyr_kinase_AS.)
IPR009030 (Growth_fac_rcpt_.)
IPR011009 (Kinase-like_dom.)
IPR013783 (Ig-like_fold.)
IPR016246 (Tyr_kinase_insulin-like_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR032675 (L_dom-like.)
Pfam PF00757 (Furin-like)
PF01030 (Recep_L_domain)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU 4D2R 4XSS 5FXQ 5FXR 5FXS 5HZN
CREDO 1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU 4D2R 4XSS 5FXQ 5FXR 5FXS 5HZN
spacer
spacer