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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1952
Target Type SINGLE PROTEIN
Preferred Name Thymidylate synthase
Synonyms TS | TS | TSase | TYMS | Thymidylate synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Thymidylate synthase SINGLE PROTEIN P04818

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1773 CAPECITABINE Thymidylate synthase inhibitor DailyMed
CHEMBL917 FLOXURIDINE Thymidylate synthase inhibitor PubMed PubMed PubMed PubMed
CHEMBL185 FLUOROURACIL Thymidylate synthase inhibitor DailyMed
CHEMBL1200373 PEMETREXED DISODIUM Thymidylate synthase inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176890
Ensembl ENSG00000176890
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004799 (thymidylate synthase activity)
GO Biological Process GO:0000083 (regulation of transcription involved in G1/S phase of mitotic cell cycle)
GO:0006206 (pyrimidine base metabolic process)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0046134 (pyrimidine nucleoside biosynthetic process)
GO:0046683 (response to organophosphorus)
GO:0048015 (phosphatidylinositol-mediated signaling)
Wikipedia Thymidylate_synthase

Target Cross References - Protein

canSAR P04818
Human Protein Atlas ENSG00000176890
Guide to Pharmacology 2642 (thymidylate synthetase)
PharmGKB PA359
Reactome REACT_152 (Cell Cycle, Mitotic.)
REACT_1698 (Metabolism of nucleotides.)
UniProt P04818

Target Cross References - Domain

InterPro IPR000398 (Thymidylate_synthase.)
IPR020940 (Thymidylate_synthase_AS.)
IPR023451 (Thymidate_synth/dCMP_Mease.)
Pfam PF00303 (Thymidylat_synt)

Target Cross References - Structure

PDBe 1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 More...
CREDO 1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 More...
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