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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1950
Target Type SINGLE PROTEIN
Preferred Name Antithrombin-III
Synonyms AT3 | ATIII | Antithrombin-III | SERPINC1 | Serpin C1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Antithrombin-III SINGLE PROTEIN P01008

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111449 Coagulation factor X/antithrombin III PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200644 FONDAPARINUX SODIUM Antithrombin-III activator 4 DailyMed
CHEMBL1201476 ENOXAPARIN SODIUM Antithrombin-III activator 4 DailyMed
CHEMBL1201448 ARDEPARIN SODIUM Antithrombin-III activator 4 DailyMed ISBN PubMed
CHEMBL1201513 HEPARIN CALCIUM Antithrombin-III activator 4 DailyMed ISBN
CHEMBL1201657 HEPARIN SODIUM Antithrombin-III activator 4 DailyMed ISBN
CHEMBL1201414 TINZAPARIN SODIUM Antithrombin-III activator 4 DailyMed ISBN
CHEMBL1201460 DALTEPARIN SODIUM Antithrombin-III activator 4 DailyMed
CHEMBL1201534 DANAPAROID SODIUM Antithrombin-III activator 4 FDA ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117601
Ensembl ENSG00000117601
GO Cellular Component GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0002020 (protease binding)
GO:0004867 (serine-type endopeptidase inhibitor activity)
GO:0008201 (heparin binding)
GO Biological Process GO:0007596 (blood coagulation)
GO:0030162 (regulation of proteolysis)
Wikipedia Antithrombin

Target Cross References - Protein

canSAR P01008
CGD Antithrombin III deficiency
Human Protein Atlas ENSG00000117601
IntAct P01008
Guide to Pharmacology 2632 (serpin peptidase inhibitor, clade C (antithrombin), member 1)
PharmGKB PA35026
Reactome REACT_604 (Hemostasis.)
UniProt B2R6P0 P01008 P78439 P78447 Q13815 Q5TC78 Q7KZ43 Q7KZ97 Q9UC78

Target Cross References - Domain

InterPro IPR000215 (Protease_inhib_I4_serpin.)
IPR015555 (Protease_inhib_serpin_AT-III.)
IPR023795 (Protease_inhib_I4_serpin_CS.)
IPR023796 (Sepin_dom.)
Pfam PF00079 (Serpin)

Target Cross References - Structure

PDBe 1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH More...
CREDO 1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH More...
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