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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1949
Target Type SINGLE PROTEIN
Preferred Name Cyclophilin A
Synonyms CYPA | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Peptidyl-prolyl cis-trans isomerase A, N-terminally processed | Rotamase A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > isomerase

Target Components

Component Description Relationship Accession
Peptidyl-prolyl cis-trans isomerase A SINGLE PROTEIN P62937

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL160 CYCLOSPORINE Cyclophilin A modulator 4 FDA PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196262
Ensembl ENSG00000196262
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003755 (peptidyl-prolyl cis-trans isomerase activity)
GO:0005515 (protein binding)
GO:0016853 (isomerase activity)
GO:0042277 (peptide binding)
GO:0044822 (poly(A) RNA binding)
GO:0046790 (virion binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0000413 (protein peptidyl-prolyl isomerization)
GO:0006278 (RNA-dependent DNA biosynthetic process)
GO:0006457 (protein folding)
GO:0016032 (viral process)
GO:0019058 (viral life cycle)
GO:0019061 (uncoating of virus)
GO:0019064 (fusion of virus membrane with host plasma membrane)
GO:0019068 (virion assembly)
GO:0019076 (viral release from host cell)
GO:0030260 (entry into host cell)
GO:0034389 (lipid particle organization)
GO:0045069 (regulation of viral genome replication)
GO:0045070 (positive regulation of viral genome replication)
GO:0050714 (positive regulation of protein secretion)
GO:0050900 (leukocyte migration)
GO:0075713 (establishment of integrated proviral latency)
Wikipedia Peptidylprolyl_isomerase_A

Target Cross References - Protein

canSAR P62937
Human Protein Atlas ENSG00000196262
IntAct P62937
Guide to Pharmacology 2751
Open Targets ENSG00000196262
PharmGKB PA33574
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-162585 (Uncoating of the HIV Virion.)
R-HSA-162588 (Budding and maturation of HIV virion.)
R-HSA-162592 (Integration of provirus.)
R-HSA-162594 (Early Phase of HIV Life Cycle.)
R-HSA-164516 (Minus-strand DNA synthesis.)
R-HSA-164525 (Plus-strand DNA synthesis.)
R-HSA-173107 (Binding and entry of HIV virion.)
R-HSA-175474 (Assembly Of The HIV Virion.)
R-HSA-180689 (APOBEC3G mediated resistance to HIV-1 infection.)
R-HSA-210991 (Basigin interactions.)
R-HSA-6798695 (Neutrophil degranulation.)
TIMBAL Cyclophilins
UniProt A8K220 P05092 P62937 Q3KQW3 Q567Q0 Q6IBU5 Q96IX3 Q9BRU4 Q9BTY9 Q9UC61

Target Cross References - Domain

InterPro IPR002130 (Cyclophilin-type_PPIase_dom.)
IPR020892 (Cyclophilin-type_PPIase_CS.)
IPR024936 (Cyclophilin-type_PPIase.)
IPR029000 (Cyclophilin-like_dom.)
Pfam PF00160 (Pro_isomerase)

Target Cross References - Structure

PDBe 1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E More...
CREDO 1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E More...
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