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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1947
Target Type SINGLE PROTEIN
Preferred Name Thyroid hormone receptor beta-1
Synonyms ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THR1 | THRB | Thyroid hormone receptor beta | c-erbA-2 | c-erbA-beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group a > nuclear hormone receptor subfamily 1 group a member 2

Target Components

Component Description Relationship Accession
Thyroid hormone receptor beta SINGLE PROTEIN P10828

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111462 Thyroid hormone receptor PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2035874 EPROTIROME Thyroid hormone receptor beta-1 agonist 3 PubMed PubMed
CHEMBL457748 MB07811 Thyroid hormone receptor beta-1 agonist 2 PubMed
CHEMBL3261331 MGL-3196 Thyroid hormone receptor beta-1 agonist 1 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151090
Ensembl ENSG00000151090
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003714 (transcription corepressor activity)
GO:0004887 (thyroid hormone receptor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0031490 (chromatin DNA binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0070324 (thyroid hormone binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007605 (sensory perception of sound)
GO:0007621 (negative regulation of female receptivity)
GO:0008016 (regulation of heart contraction)
GO:0008050 (female courtship behavior)
GO:0009887 (organ morphogenesis)
GO:0030522 (intracellular receptor signaling pathway)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0060509 (Type I pneumocyte differentiation)
Wikipedia Thyroid_hormone_receptor_beta

Target Cross References - Protein

canSAR P10828
CGD Thyroid hormone resistance, general; Thyroid hormone resistance, selective pituitary
Human Protein Atlas ENSG00000151090
IntAct P10828
Guide to Pharmacology 589
Open Targets ENSG00000151090
PharmGKB PA36508
Pharos P10828 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt B3KU79 P10828 P37243 Q13986 Q3KP35 Q6WGL2 Q9UD41

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR001728 (ThyrH_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1
CREDO 1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1
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