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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1944
Target Type SINGLE PROTEIN
Preferred Name Neprilysin
Synonyms Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | Neprilysin | Neutral endopeptidase 24.11 | Neutral endopeptidase | SFE | Skin fibroblast elastase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m13 family

Target Components

Component Description Relationship Accession
Neprilysin SINGLE PROTEIN P08473

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3137301 SACUBITRIL Neprilysin inhibitor 4 FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196549
Ensembl ENSG00000196549
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005903 (brush border)
GO:0005925 (focal adhesion)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0044306 (neuron projection terminus)
GO:0045202 (synapse)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008238 (exopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001822 (kidney development)
GO:0002003 (angiotensin maturation)
GO:0006508 (proteolysis)
GO:0006518 (peptide metabolic process)
GO:0019233 (sensory perception of pain)
GO:0046449 (creatinine metabolic process)
GO:0050435 (beta-amyloid metabolic process)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071492 (cellular response to UV-A)
GO:0071493 (cellular response to UV-B)
GO:0090399 (replicative senescence)
Wikipedia Neprilysin

Target Cross References - Protein

canSAR P08473
Human Protein Atlas ENSG00000196549
IntAct P08473
Guide to Pharmacology 1611
Open Targets ENSG00000196549
PharmGKB PA30864
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt A8K6U6 D3DNJ9 P08473 Q3MIX4

Target Cross References - Domain

InterPro IPR000718 (Peptidase_M13.)
IPR008753 (Peptidase_M13_N.)
IPR018497 (Peptidase_M13_C.)
IPR024079 (MetalloPept_cat_dom.)
IPR029727 (MME/CD10/NEP.)
Pfam PF01431 (Peptidase_M13)
PF05649 (Peptidase_M13_N)

Target Cross References - Structure

PDBe 1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH
CREDO 1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH
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