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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1942
Target Type SINGLE PROTEIN
Preferred Name Alpha-2b adrenergic receptor
Synonyms ADRA2B | ADRA2L1 | ADRA2RL1 | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenergic receptor | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-2B adrenergic receptor SINGLE PROTEIN P18089

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY
CHEMBL2095203 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2095158 Adrenergic receptor alpha-2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004938 (alpha2-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0051379 (epinephrine binding)
GO Biological Process GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0019229 (regulation of vasoconstriction)
GO:0030168 (platelet activation)
GO:0032148 (activation of protein kinase B activity)
GO:0032811 (negative regulation of epinephrine secretion)
GO:0035625 (epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway)
GO:0045666 (positive regulation of neuron differentiation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0071883 (activation of MAPK activity by adrenergic receptor signaling pathway)
Wikipedia Alpha-2B_adrenergic_receptor

Target Cross References - Protein

canSAR P18089
IntAct P18089
Guide to Pharmacology 26
Open Targets
PharmGKB PA36
Pharos P18089 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-392023 (Adrenaline signalling through Alpha-2 adrenergic receptor.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-418597 (G alpha (z) signalling events.)
UniProt P18089 Q4TUH9 Q53RF2 Q9BZK0

Target Cross References - Domain

InterPro IPR000207 (ADRA2B_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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