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Target Report Card

Target Name and Classification

Target ID CHEMBL1937
Preferred Name Histone deacetylase 2
Synonyms HD2 | HDAC2 | Histone deacetylase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class i

Target Components

Component Description Relationship Accession
Histone deacetylase 2 SINGLE PROTEIN Q92769

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111429 Histone deacetylase (HDAC1 and HDAC2) PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 2 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196591
Ensembl ENSG00000196591
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005654 (nucleoplasm)
GO:0035098 (ESC/E(Z) complex)
GO:0005634 (nucleus)
GO:0016580 (Sin3 complex)
GO:0043234 (protein complex)
GO:0005737 (cytoplasm)
GO:0016581 (NuRD complex)
GO Molecular Function GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0003682 (chromatin binding)
GO:0004407 (histone deacetylase activity)
GO:0043565 (sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0019213 (deacetylase activity)
GO:0051059 (NF-kappaB binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0019899 (enzyme binding)
GO:0033558 (protein deacetylase activity)
GO:0044822 (poly(A) RNA binding)
GO:0008134 (transcription factor binding)
GO Biological Process GO:0001975 (response to amphetamine)
GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0032922 (circadian regulation of gene expression)
GO:0035094 (response to nicotine)
GO:0040029 (regulation of gene expression, epigenetic)
GO:0045786 (negative regulation of cell cycle)
GO:0061029 (eyelid development in camera-type eye)
GO:0006325 (chromatin organization)
GO:0007596 (blood coagulation)
GO:0010977 (negative regulation of neuron projection development)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0061000 (negative regulation of dendritic spine development)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0045814 (negative regulation of gene expression, epigenetic)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0070301 (cellular response to hydrogen peroxide)
GO:2000757 (negative regulation of peptidyl-lysine acetylation)
GO:0006344 (maintenance of chromatin silencing)
GO:0009913 (epidermal cell differentiation)
GO:0010467 (gene expression)
GO:0016358 (dendrite development)
GO:0016575 (histone deacetylation)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0042733 (embryonic digit morphogenesis)
GO:0045862 (positive regulation of proteolysis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0070933 (histone H4 deacetylation)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0008284 (positive regulation of cell proliferation)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0031000 (response to caffeine)
GO:0045347 (negative regulation of MHC class II biosynthetic process)
GO:0048149 (behavioral response to ethanol)
GO:0060789 (hair follicle placode formation)
GO:0070932 (histone H3 deacetylation)
GO:0071300 (cellular response to retinoic acid)
GO:0032732 (positive regulation of interleukin-1 production)
GO:0034605 (cellular response to heat)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0043044 (ATP-dependent chromatin remodeling)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:1903351 (cellular response to dopamine)
GO:0003300 (cardiac muscle hypertrophy)
GO:0032496 (response to lipopolysaccharide)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0043392 (negative regulation of DNA binding)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0055093 (response to hyperoxia)
GO:0061198 (fungiform papilla formation)
Wikipedia Histone_deacetylase_2

Target Cross References - Protein

canSAR Q92769
Human Protein Atlas ENSG00000196591
IntAct Q92769
Guide to Pharmacology 2616 (histone deacetylase 2)
PharmGKB PA29227
UniProt Q5SZ86 B4DL58 Q5SRI8 Q92769 E1P561 Q8NEH4

Target Cross References - Domain

InterPro IPR003084 (His_deacetylse_1.)
IPR000286 (His_deacetylse.)
IPR023801 (His_deacetylse_dom.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure