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Target Report Card

Target Name and Classification

Target ID CHEMBL1937
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 2
Synonyms HD2 | HDAC2 | Histone deacetylase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class i

Target Components

Component Description Relationship Accession
Histone deacetylase 2 SINGLE PROTEIN Q92769

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY
CHEMBL2111429 Histone deacetylase (HDAC1 and HDAC2) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 2 inhibitor 4 DailyMed
CHEMBL272980 MOCETINOSTAT Histone deacetylase 2 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196591
Ensembl ENSG00000196591
GO Cellular Component GO:0000785 (chromatin)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016580 (Sin3 complex)
GO:0016581 (NuRD complex)
GO:0035098 (ESC/E(Z) complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0003682 (chromatin binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0019213 (deacetylase activity)
GO:0019899 (enzyme binding)
GO:0031072 (heat shock protein binding)
GO:0031492 (nucleosomal DNA binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044822 (poly(A) RNA binding)
GO:0051059 (NF-kappaB binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001975 (response to amphetamine)
GO:0003300 (cardiac muscle hypertrophy)
GO:0006338 (chromatin remodeling)
GO:0006344 (maintenance of chromatin silencing)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007596 (blood coagulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0009913 (epidermal cell differentiation)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0010977 (negative regulation of neuron projection development)
GO:0016358 (dendrite development)
GO:0016568 (chromatin modification)
GO:0016575 (histone deacetylation)
GO:0031000 (response to caffeine)
GO:0032496 (response to lipopolysaccharide)
GO:0032732 (positive regulation of interleukin-1 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032922 (circadian regulation of gene expression)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0034605 (cellular response to heat)
GO:0035094 (response to nicotine)
GO:0042220 (response to cocaine)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042493 (response to drug)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0042733 (embryonic digit morphogenesis)
GO:0043044 (ATP-dependent chromatin remodeling)
GO:0043066 (negative regulation of apoptotic process)
GO:0043392 (negative regulation of DNA binding)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0045347 (negative regulation of MHC class II biosynthetic process)
GO:0045862 (positive regulation of proteolysis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048149 (behavioral response to ethanol)
GO:0048511 (rhythmic process)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0055093 (response to hyperoxia)
GO:0060789 (hair follicle placode formation)
GO:0061000 (negative regulation of dendritic spine development)
GO:0061029 (eyelid development in camera-type eye)
GO:0061198 (fungiform papilla formation)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0071300 (cellular response to retinoic acid)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1903351 (cellular response to dopamine)
GO:2000757 (negative regulation of peptidyl-lysine acetylation)
Wikipedia Histone_deacetylase_2

Target Cross References - Protein

canSAR Q92769
Human Protein Atlas ENSG00000196591
IntAct Q92769
Guide to Pharmacology 2616
Open Targets ENSG00000196591
PharmGKB PA29227
Reactome R-HSA-193670 (p75NTR negatively regulates cell cycle via SC1.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214815 (HDACs deacetylate histones.)
R-HSA-427389 (ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.)
R-HSA-427413 (NoRC negatively regulates rRNA expression.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-73762 (RNA Polymerase I Transcription Initiation.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B3KRS5 B4DL58 E1P561 Q5SRI8 Q5SZ86 Q8NEH4 Q92769

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR003084 (His_deacetylse_1.)
IPR023801 (His_deacetylse_dom.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure

PDBe 3MAX 4LXZ 4LY1 5IWG 5IX0
CREDO 3MAX 4LXZ 4LY1 5IWG 5IX0
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