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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1935
Target Type SINGLE PROTEIN
Preferred Name Aldehyde dehydrogenase
Synonyms ALDH class 2 | ALDH-E2 | ALDH2 | ALDHI | ALDM | Aldehyde dehydrogenase, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Aldehyde dehydrogenase, mitochondrial SINGLE PROTEIN P05091

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542434 Aldehyde dehydrogenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL964 DISULFIRAM Aldehyde dehydrogenase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111275
Ensembl ENSG00000111275
GO Cellular Component GO:0005759 (mitochondrial matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0004030 (aldehyde dehydrogenase [NAD(P)+] activity)
GO:0009055 (electron carrier activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006066 (alcohol metabolic process)
GO:0006068 (ethanol catabolic process)
GO:0006069 (ethanol oxidation)
GO:0006805 (xenobiotic metabolic process)
GO:0007268 (synaptic transmission)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0044281 (small molecule metabolic process)
Wikipedia ALDH2

Target Cross References - Protein

canSAR P05091
Human Protein Atlas ENSG00000111275
IntAct P05091
PharmGKB PA24696
UniProt P05091 Q03639 Q6IB13 Q6IV71

Target Cross References - Domain

InterPro IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)

Target Cross References - Structure

PDBe 1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 More...
CREDO 1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 More...
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