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Target Report Card

Target Name and Classification

Target ID CHEMBL1929
Target Type SINGLE PROTEIN
Preferred Name Xanthine dehydrogenase
Synonyms XDH | XDHA | XOR | Xanthine dehydrogenase | Xanthine dehydrogenase/oxidase | Xanthine oxidase | Xanthine oxidoreductase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Xanthine dehydrogenase/oxidase SINGLE PROTEIN P47989

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1467 ALLOPURINOL Xanthine dehydrogenase inhibitor 4 FDA
CHEMBL1089221 BENDAZAC Xanthine dehydrogenase inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL1164729 FEBUXOSTAT Xanthine dehydrogenase inhibitor 4 DailyMed
CHEMBL1200477 ALLOPURINOL SODIUM Xanthine dehydrogenase inhibitor 4 FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000158125
Ensembl ENSG00000158125
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO:0016529 (sarcoplasmic reticulum)
GO Molecular Function GO:0004854 (xanthine dehydrogenase activity)
GO:0004855 (xanthine oxidase activity)
GO:0005506 (iron ion binding)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors)
GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors)
GO:0042803 (protein homodimerization activity)
GO:0043546 (molybdopterin cofactor binding)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0051536 (iron-sulfur cluster binding)
GO:0051537 (2 iron, 2 sulfur cluster binding)
GO Biological Process GO:0001933 (negative regulation of protein phosphorylation)
GO:0001937 (negative regulation of endothelial cell proliferation)
GO:0006195 (purine nucleotide catabolic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007595 (lactation)
GO:0009115 (xanthine catabolic process)
GO:0010629 (negative regulation of gene expression)
GO:0022900 (electron transport chain)
GO:0030856 (regulation of epithelial cell differentiation)
GO:0045602 (negative regulation of endothelial cell differentiation)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0055114 (oxidation-reduction process)
GO:1900745 (positive regulation of p38MAPK cascade)
GO:1900747 (negative regulation of vascular endothelial growth factor signaling pathway)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2001213 (negative regulation of vasculogenesis)
Wikipedia Xanthine_dehydrogenase

Target Cross References - Protein

canSAR P47989
CGD Xanthinuria, type I
Human Protein Atlas ENSG00000158125
IntAct P47989
Guide to Pharmacology 2646
Open Targets ENSG00000158125
PharmGKB PA37404
Reactome R-HSA-74259 (Purine catabolism.)
R-HSA-8851680 (Butyrophilin (BTN) family interactions.)
UniProt P47989 Q16681 Q16712 Q4PJ16

Target Cross References - Domain

InterPro IPR000674 (Ald_Oxase/Xan_DH_a/b.)
IPR001041 (2Fe-2S_ferredoxin-type.)
IPR002346 (Mopterin_DH_FAD-bd.)
IPR002888 (2Fe-2S-bd.)
IPR005107 (CO_DH_flav_C.)
IPR006058 (2Fe2S_fd_BS.)
IPR008274 (AldOxase/xan_DH_Mopterin-bd.)
IPR014307 (Xanthine_DH_ssu.)
IPR016166 (FAD-bd_2.)
IPR016208 (Ald_Oxase/xanthine_DH.)
IPR022407 (OxRdtase_Mopterin_BS.)
IPR036010 (2Fe-2S_ferredoxin-like_sf.)
IPR036318 (FAD-bd_2-like_sf.)
IPR036683 (CO_DH_flav_C_dom_sf.)
IPR036856 (Ald_Oxase/Xan_DH_a/b_sf.)
IPR036884 (2Fe-2S-bd_dom_sf.)
IPR037165 (AldOxase/xan_DH_Mopterin-bd_sf.)
Pfam PF00111 (Fer2)
PF00941 (FAD_binding_5)
PF01315 (Ald_Xan_dh_C)
PF01799 (Fer2_2)
PF02738 (Ald_Xan_dh_C2)
PF03450 (CO_deh_flav_C)

Target Cross References - Structure

PDBe 2CKJ 2E1Q
CREDO 2CKJ 2E1Q
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