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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1914
Target Type SINGLE PROTEIN
Preferred Name Butyrylcholinesterase
Synonyms Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase | CHE1 | Choline esterase II | Cholinesterase | Pseudocholinesterase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Cholinesterase SINGLE PROTEIN P06276

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095233 Cholinesterases; ACHE & BCHE SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114200
Ensembl ENSG00000114200
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005641 (nuclear envelope lumen)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0016020 (membrane)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0003824 (catalytic activity)
GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0019899 (enzyme binding)
GO:0033265 (choline binding)
GO:0042802 (identical protein binding)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0007584 (response to nutrient)
GO:0007612 (learning)
GO:0008285 (negative regulation of cell proliferation)
GO:0014016 (neuroblast differentiation)
GO:0019695 (choline metabolic process)
GO:0042493 (response to drug)
GO:0043279 (response to alkaloid)
GO:0050783 (cocaine metabolic process)
GO:0050805 (negative regulation of synaptic transmission)
GO:0051384 (response to glucocorticoid)
GO:0051593 (response to folic acid)
Wikipedia Butyrylcholinesterase

Target Cross References - Protein

canSAR P06276
CGD Butyrlcholinesterase deficiency
Human Protein Atlas ENSG00000114200
IntAct P06276
Guide to Pharmacology 2471
MICAD NBK23388 (Butyrylcholinesterase (BChE, BuChE))
Open Targets ENSG00000114200
PharmGKB PA25294
Reactome R-HSA-112311 (Neurotransmitter Clearance In The Synaptic Cleft.)
R-HSA-1483191 (Synthesis of PC.)
R-HSA-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
UniProt A8K7P8 P06276

Target Cross References - Domain

InterPro IPR000997 (Cholinesterase.)
IPR002018 (CarbesteraseB.)
IPR014788 (AChE_tetra.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
PF08674 (AChE_tetra)

Target Cross References - Structure

PDBe 1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2PM8 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ More...
CREDO 1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2PM8 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ More...
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