ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1908
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 11B1
Synonyms CYP11B1 | CYPXIB1 | Cytochrome P-450c11 | Cytochrome P450 11B1, mitochondrial | Cytochrome P450C11 | S11BH | Steroid 11-beta-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 11 > cytochrome p450 family 11b > cytochrome p450 11b1

Target Components

Component Description Relationship Accession
Cytochrome P450 11B1, mitochondrial SINGLE PROTEIN P15538

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1670 MITOTANE Cytochrome P450 11B1 inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160882
Ensembl ENSG00000160882
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004507 (steroid 11-beta-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0047783 (corticosterone 18-monooxygenase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006700 (C21-steroid hormone biosynthetic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0006955 (immune response)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008217 (regulation of blood pressure)
GO:0016125 (sterol metabolic process)
GO:0032342 (aldosterone biosynthetic process)
GO:0032870 (cellular response to hormone stimulus)
GO:0034651 (cortisol biosynthetic process)
GO:0035865 (cellular response to potassium ion)
GO:0042593 (glucose homeostasis)
GO:0044550 (secondary metabolite biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0071375 (cellular response to peptide hormone stimulus)
Wikipedia Steroid_11-beta-hydroxylase

Target Cross References - Protein

canSAR P15538
CGD Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency; Glucocorticoid-remediable aldosteronism
Human Protein Atlas ENSG00000160882
Guide to Pharmacology 1359
MICAD NBK23130 (11Beta-hydroxylase)
Open Targets ENSG00000160882
PharmGKB PA133
Reactome R-HSA-194002 (Glucocorticoid biosynthesis.)
R-HSA-211976 (Endogenous sterols.)
UniProt P15538 Q14095 Q4VAQ8 Q4VAQ9 Q9UML2

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002399 (Cyt_P450_mitochondrial.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)
spacer
spacer