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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1907
Target Type SINGLE PROTEIN
Preferred Name Aminopeptidase N
Synonyms ANPEP | AP-M | AP-N | APN | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N | CD13 | CD_antigen=CD13 | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | PEPN | gp150 | hAPN
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Aminopeptidase N SINGLE PROTEIN P15144

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166825
Ensembl ENSG00000166825
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031983 (vesicle lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0004177 (aminopeptidase activity)
GO:0004872 (receptor activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006508 (proteolysis)
GO:0006725 (cellular aromatic compound metabolic process)
GO:0007275 (multicellular organism development)
GO:0016032 (viral process)
GO:0030154 (cell differentiation)
GO:0035814 (negative regulation of renal sodium excretion)
GO:0043171 (peptide catabolic process)
GO:0046718 (viral entry into host cell)
Wikipedia Alanine_aminopeptidase

Target Cross References - Protein

canSAR P15144
Human Protein Atlas ENSG00000166825
IntAct P15144
Guide to Pharmacology 1560
Open Targets ENSG00000166825
PharmGKB PA24815
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt P15144 Q16728 Q6GT90 Q8IUK3 Q8IVH3 Q9UCE0

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)

Target Cross References - Structure

PDBe 4FYQ 4FYR 4FYS 4FYT
CREDO 4FYQ 4FYR 4FYS 4FYT
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