ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1905
Target Type SINGLE PROTEIN
Preferred Name Fibronectin receptor beta
Synonyms CD_antigen=CD29 | FNRB | Fibronectin receptor subunit beta | GPIIA | Glycoprotein IIa | ITGB1 | Integrin beta-1 | MDF2 | MSK12 | VLA-4 subunit beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin beta-1 SINGLE PROTEIN P05556

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907599 Integrin alpha-4/beta-1 PROTEIN COMPLEX
CHEMBL3885597 ITGB1-ITGA9 complex PROTEIN COMPLEX
CHEMBL3885596 ITGA6-ITGB1 complex PROTEIN COMPLEX
CHEMBL3430895 Integrin alpha-10/Integrin beta-1 PROTEIN COMPLEX
CHEMBL3137278 Integrin alpha1/beta1 complex PROTEIN COMPLEX
CHEMBL2111425 Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) PROTEIN COMPLEX GROUP
CHEMBL3137268 Integrin alpha2/beta1 PROTEIN COMPLEX
CHEMBL2111407 Integrin alpha-V/beta-1 PROTEIN COMPLEX
CHEMBL2095226 Integrin alpha-5/beta-1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000150093
Ensembl ENSG00000150093
GO Cellular Component GO:0001726 (ruffle)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030175 (filopodium)
GO:0031410 (cytoplasmic vesicle)
GO:0031594 (neuromuscular junction)
GO:0032154 (cleavage furrow)
GO:0032587 (ruffle membrane)
GO:0034665 (integrin alpha1-beta1 complex)
GO:0034666 (integrin alpha2-beta1 complex)
GO:0034667 (integrin alpha3-beta1 complex)
GO:0034677 (integrin alpha7-beta1 complex)
GO:0034678 (integrin alpha8-beta1 complex)
GO:0034680 (integrin alpha10-beta1 complex)
GO:0034681 (integrin alpha11-beta1 complex)
GO:0035748 (myelin sheath abaxonal region)
GO:0042383 (sarcolemma)
GO:0042470 (melanosome)
GO:0042995 (cell projection)
GO:0043197 (dendritic spine)
GO:0043235 (receptor complex)
GO:0045121 (membrane raft)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0055037 (recycling endosome)
GO:0070062 (extracellular exosome)
GO:0071438 (invadopodium membrane)
GO:0097060 (synaptic membrane)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0001968 (fibronectin binding)
GO:0002020 (protease binding)
GO:0003779 (actin binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0015026 (coreceptor activity)
GO:0019960 (C-X3-C chemokine binding)
GO:0038023 (signaling receptor activity)
GO:0043236 (laminin binding)
GO:0044877 (macromolecular complex binding)
GO:0045296 (cadherin binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0050839 (cell adhesion molecule binding)
GO:0098639 (collagen binding involved in cell-matrix adhesion)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0001701 (in utero embryonic development)
GO:0001708 (cell fate specification)
GO:0002042 (cell migration involved in sprouting angiogenesis)
GO:0006968 (cellular defense response)
GO:0007155 (cell adhesion)
GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007161 (calcium-independent cell-matrix adhesion)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0008354 (germ cell migration)
GO:0008542 (visual learning)
GO:0010710 (regulation of collagen catabolic process)
GO:0016032 (viral process)
GO:0016477 (cell migration)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0021943 (formation of radial glial scaffolds)
GO:0030183 (B cell differentiation)
GO:0030198 (extracellular matrix organization)
GO:0031175 (neuron projection development)
GO:0031589 (cell-substrate adhesion)
GO:0031623 (receptor internalization)
GO:0033627 (cell adhesion mediated by integrin)
GO:0033631 (cell-cell adhesion mediated by integrin)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0035024 (negative regulation of Rho protein signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0043149 (stress fiber assembly)
GO:0043547 (positive regulation of GTPase activity)
GO:0045214 (sarcomere organization)
GO:0045596 (negative regulation of cell differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0046718 (viral entry into host cell)
GO:0048333 (mesodermal cell differentiation)
GO:0048675 (axon extension)
GO:0048738 (cardiac muscle tissue development)
GO:0048813 (dendrite morphogenesis)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
GO:0051726 (regulation of cell cycle)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055007 (cardiac muscle cell differentiation)
GO:0071404 (cellular response to low-density lipoprotein particle stimulus)
GO:0071711 (basement membrane organization)
GO:1903078 (positive regulation of protein localization to plasma membrane)
GO:2000273 (positive regulation of receptor activity)
GO:2000811 (negative regulation of anoikis)
Wikipedia CD29

Target Cross References - Protein

canSAR P05556
Human Protein Atlas ENSG00000150093
IntAct P05556
Guide to Pharmacology 2455
Open Targets ENSG00000150093
PharmGKB PA29953
Reactome R-HSA-1566948 (Elastic fibre formation.)
R-HSA-1566977 (Fibronectin matrix formation.)
R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-210991 (Basigin interactions.)
R-HSA-2129379 (Molecules associated with elastic fibres.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000157 (Laminin interactions.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-416700 (Other semaphorin interactions.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-446343 (Localization of the PINCH-ILK-PARVIN complex to focal adhesions.)
R-HSA-447041 (CHL1 interactions.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-75892 (Platelet Adhesion to exposed collagen.)
R-HSA-8874081 (MET activates PTK2 signaling.)
R-HSA-8875513 (MET interacts with TNS proteins.)
TIMBAL Integrins
UniProt A8K6N2 D3DRX9 D3DRY3 D3DRY4 D3DRY5 P05556 P78466 P78467 Q13089 Q13090 Q13091 Q13212 Q14622 Q14647 Q29RW2 Q7Z3V1 Q8WUM6

Target Cross References - Domain

InterPro IPR002369 (Integrin_bsu_VWA.)
IPR012896 (Integrin_bsu_tail.)
IPR013111 (EGF_extracell.)
IPR014836 (Integrin_bsu_cyt_dom.)
IPR015812 (Integrin_bsu.)
IPR016201 (PSI.)
IPR027071 (Integrin_beta-1.)
IPR032695 (Integrin_dom_sf.)
IPR033760 (Integrin_beta_N.)
IPR036349 (Integrin_bsu_tail_dom_sf.)
IPR036465 (vWFA_dom_sf.)
Pfam PF00362 (Integrin_beta)
PF07965 (Integrin_B_tail)
PF07974 (EGF_2)
PF08725 (Integrin_b_cyt)
PF17205 (PSI_integrin)

Target Cross References - Structure

PDBe 3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4
CREDO 3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4
spacer
spacer