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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1904
Target Type SINGLE PROTEIN
Preferred Name Glutamate [NMDA] receptor subunit epsilon 2
Synonyms GRIN2B | GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | Glutamate receptor ionotropic, NMDA 2B | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | NMDAR2B | NMDAR2B | NR2B | NR3 | hNR3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2B SINGLE PROTEIN Q13224

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094124 Glutamate [NMDA] receptor PROTEIN COMPLEX GROUP
CHEMBL1907603 Glutamate NMDA receptor; GRIN1/GRIN2B PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000273079
Ensembl ENSG00000273079
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0097060 (synaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016594 (glycine binding)
GO:0016595 (glutamate binding)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0038023 (signaling receptor activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006811 (ion transport)
GO:0007215 (glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007275 (multicellular organism development)
GO:0007420 (brain development)
GO:0007611 (learning or memory)
GO:0019722 (calcium-mediated signaling)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0045471 (response to ethanol)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048167 (regulation of synaptic plasticity)
GO:0051290 (protein heterotetramerization)
GO:0060079 (excitatory postsynaptic potential)
GO:0097553 (calcium ion transmembrane import into cytosol)
GO:0098976 (excitatory chemical synaptic transmission)
GO:1901216 (positive regulation of neuron death)
GO:1902951 (negative regulation of dendritic spine maintenance)
GO:2001056 (positive regulation of cysteine-type endopeptidase activity)
Wikipedia GRIN2B

Target Cross References - Protein

canSAR Q13224
CGD Mental retardation, autosomal dominant 6
Human Protein Atlas ENSG00000273079
IntAct Q13224
Open Targets ENSG00000273079
PharmGKB PA28980
Pharos Q13224 (Tclin)
Reactome R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6794361 (Neurexins and neuroligins.)
R-HSA-8849932 (Synaptic adhesion-like molecules.)
UniProt Q12919 Q13220 Q13224 Q13225 Q14CU4 Q9UM56

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR018884 (NMDAR2_C.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10565 (NMDAR2_C)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 5EWJ 5EWL 5EWM
CREDO 5EWJ 5EWL 5EWM
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