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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1903
Preferred Name GABA transporter 1
Synonyms GABATR | GABT1 | GAT-1 | GAT1 | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Solute carrier family 6 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Sodium- and chloride-dependent GABA transporter 1 SINGLE PROTEIN P30531

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1695 TIAGABINE HYDROCHLORIDE GABA transporter 1 inhibitor 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000157103
Ensembl ENSG00000157103
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0043005 (neuron projection)
GO Molecular Function GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0005332 (gamma-aminobutyric acid:sodium symporter activity)
GO:0015293 (symporter activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006836 (neurotransmitter transport)
GO:0007268 (chemical synaptic transmission)
GO:0007612 (learning)
GO:0009636 (response to toxic substance)
GO:0009744 (response to sucrose)
GO:0010033 (response to organic substance)
GO:0010243 (response to organonitrogen compound)
GO:0010288 (response to lead ion)
GO:0014054 (positive regulation of gamma-aminobutyric acid secretion)
GO:0014070 (response to organic cyclic compound)
GO:0014074 (response to purine-containing compound)
GO:0015812 (gamma-aminobutyric acid transport)
GO:0032229 (negative regulation of synaptic transmission, GABAergic)
GO:0032355 (response to estradiol)
GO:0042220 (response to cocaine)
GO:0051260 (protein homooligomerization)
GO:0051592 (response to calcium ion)
GO:0051939 (gamma-aminobutyric acid import)
GO:0055085 (transmembrane transport)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
Wikipedia GABA_transporter_1

Target Cross References - Protein

canSAR P30531
Human Protein Atlas ENSG00000157103
IntAct P30531
Guide to Pharmacology 929
Open Targets ENSG00000157103
PharmGKB PA309
Reactome R-HSA-442660 (Na+/Cl- dependent neurotransmitter transporters.)
R-HSA-888593 (Reuptake of GABA.)
UniProt P30531 Q8N4K8

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR002980 (Na/ntran_symport_GABA_GAT1.)
Pfam PF00209 (SNF)