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Target Report Card

Target Name and Classification

Target ID CHEMBL1893
Target Type SINGLE PROTEIN
Preferred Name Synaptic vesicular amine transporter
Synonyms Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | Synaptic vesicular amine transporter | VAT2 | VMAT2 | Vesicular amine transporter 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc18 family of vesicular amine transporters

Target Components

Component Description Relationship Accession
Synaptic vesicular amine transporter SINGLE PROTEIN Q05940

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL612 DEXTROAMPHETAMINE Synaptic vesicular amine transporter inhibitor 4 PubMed PubMed
CHEMBL772 RESERPINE Synaptic vesicular amine transporter inhibitor 4 DailyMed ISBN
CHEMBL117785 TETRABENAZINE Synaptic vesicular amine transporter inhibitor 4 DailyMed
CHEMBL1668 RESCINNAMINE Synaptic vesicular amine transporter inhibitor 4 PubMed
CHEMBL1200515 DESERPIDINE Synaptic vesicular amine transporter inhibitor 4 DailyMed DailyMed
CHEMBL1200782 DEXTROAMPHETAMINE ADIPATE Synaptic vesicular amine transporter inhibitor 4 PubMed PubMed
CHEMBL1200992 DEXTROAMPHETAMINE SACCHARATE Synaptic vesicular amine transporter inhibitor 4 PubMed PubMed
CHEMBL1201178 LISDEXAMFETAMINE DIMESYLATE Synaptic vesicular amine transporter inhibitor 4 DailyMed PubMed PubMed
CHEMBL3544906 BENZPHETAMINE HYDROCHLORIDE Synaptic vesicular amine transporter inhibitor 4 DailyMed PubMed PubMed
CHEMBL3544971 DEXTROAMPHETAMINE SULFATE Synaptic vesicular amine transporter inhibitor 4 PubMed PubMed
CHEMBL2364639 VALBENAZINE Synaptic vesicular amine transporter inhibitor 3 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165646
Ensembl ENSG00000165646
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0030672 (synaptic vesicle membrane)
GO:0031045 (dense core granule)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043679 (axon terminus)
GO:0044297 (cell body)
GO:0070083 (clathrin-sculpted monoamine transport vesicle membrane)
GO Molecular Function GO:0005275 (amine transmembrane transporter activity)
GO:0008144 (drug binding)
GO:0008504 (monoamine transmembrane transporter activity)
GO:0015222 (serotonin transmembrane transporter activity)
GO:0019899 (enzyme binding)
GO:0031072 (heat shock protein binding)
GO Biological Process GO:0001975 (response to amphetamine)
GO:0006810 (transport)
GO:0006836 (neurotransmitter transport)
GO:0006837 (serotonin transport)
GO:0007268 (chemical synaptic transmission)
GO:0007269 (neurotransmitter secretion)
GO:0007568 (aging)
GO:0007626 (locomotory behavior)
GO:0009635 (response to herbicide)
GO:0009636 (response to toxic substance)
GO:0009791 (post-embryonic development)
GO:0010038 (response to metal ion)
GO:0010043 (response to zinc ion)
GO:0015842 (aminergic neurotransmitter loading into synaptic vesicle)
GO:0015844 (monoamine transport)
GO:0015872 (dopamine transport)
GO:0030073 (insulin secretion)
GO:0032456 (endocytic recycling)
GO:0035690 (cellular response to drug)
GO:0042137 (sequestering of neurotransmitter)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0042593 (glucose homeostasis)
GO:0042594 (response to starvation)
GO:0051412 (response to corticosterone)
GO:0051589 (negative regulation of neurotransmitter transport)
GO:0055085 (transmembrane transport)
GO:0071242 (cellular response to ammonium ion)
GO:0098700 (neurotransmitter loading into synaptic vesicle)
GO:1903427 (negative regulation of reactive oxygen species biosynthetic process)
Wikipedia Vesicular_monoamine_transporter_2

Target Cross References - Protein

canSAR Q05940
Human Protein Atlas ENSG00000165646
Guide to Pharmacology 1012
MICAD NBK23463 (Type 2 vesicular monoamine transporter (VMAT2))
NBK23597 (Type 2 vesicular monoamine transporter (VMAT2))
Open Targets ENSG00000165646
PharmGKB PA325
Reactome R-HSA-181429 (Serotonin Neurotransmitter Release Cycle.)
R-HSA-181430 (Norepinephrine Neurotransmitter Release Cycle.)
R-HSA-212676 (Dopamine Neurotransmitter Release Cycle.)
R-HSA-442660 (Na+/Cl- dependent neurotransmitter transporters.)
UniProt B2RC96 D3DRC4 Q05940 Q15876 Q4G147 Q5VW49 Q9H3P6

Target Cross References - Domain

InterPro IPR011701 (MFS.)
IPR020846 (MFS_dom.)
Pfam PF07690 (MFS_1)
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