ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1892
Target Type SINGLE PROTEIN
Preferred Name Glutamate carboxypeptidase II
Synonyms Cell growth-inhibiting gene 27 protein | FGCP | FOLH | FOLH1 | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | GCPII | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSM | PSMA | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mh clan > metallo protease m28 family > metallo protease m28b subfamily

Target Components

Component Description Relationship Accession
Glutamate carboxypeptidase 2 SINGLE PROTEIN Q04609

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109555 MDX-070 Glutamate carboxypeptidase II other 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000086205
Ensembl ENSG00000086205
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004180 (carboxypeptidase activity)
GO:0004181 (metallocarboxypeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0016805 (dipeptidase activity)
GO:0046872 (metal ion binding)
GO:1904492 (Ac-Asp-Glu binding)
GO:1904493 (tetrahydrofolyl-poly(glutamate) polymer binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0006760 (folic acid-containing compound metabolic process)
GO:0008152 (metabolic process)
GO:0008652 (cellular amino acid biosynthetic process)
GO:0035609 (C-terminal protein deglutamylation)
Wikipedia Glutamate_carboxypeptidase_II

Target Cross References - Protein

canSAR Q04609
Human Protein Atlas ENSG00000086205
IntAct Q04609
Guide to Pharmacology 1606
MICAD NBK23237 (Prostate-specific membrane antigen (PSMA))
Open Targets ENSG00000086205
PharmGKB PA28205
Reactome R-HSA-70614 (Amino acid synthesis and interconversion (transamination).)
UniProt A4UU12 A9CB79 B7Z312 B7Z343 D3DQS5 E9PDX8 O43748 Q04609 Q16305 Q541A4 Q8TAY3 Q9NP15 Q9NYE2 Q9P1P8

Target Cross References - Domain

InterPro IPR003137 (PA_domain.)
IPR007365 (TFR-like_dimer_dom.)
IPR007484 (Peptidase_M28.)
Pfam PF02225 (PA)
PF04253 (TFR_dimer)
PF04389 (Peptidase_M28)

Target Cross References - Structure

PDBe 1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW More...
CREDO 1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW More...
spacer
spacer