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Target Report Card

Target Name and Classification

Target ID CHEMBL1889
Target Type SINGLE PROTEIN
Preferred Name Vasopressin V1a receptor
Synonyms AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1aR | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1a receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > vasopressin and oxytocin receptor

Target Components

Component Description Relationship Accession
Vasopressin V1a receptor SINGLE PROTEIN P37288

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111456 Vasopressin V1 receptor PROTEIN FAMILY
CHEMBL2363078 Vasopressin receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201108 CONIVAPTAN HYDROCHLORIDE Vasopressin V1a receptor antagonist 4 DailyMed FDA
CHEMBL1201528 VASOPRESSIN TANNATE Vasopressin V1a receptor agonist 4 DailyMed DailyMed IUPHAR
CHEMBL419667 RELCOVAPTAN Vasopressin V1a receptor antagonist 2 PubMed PubMed
CHEMBL244243 SRX246 Vasopressin V1a receptor antagonist 2 PubMed PubMed
CHEMBL1817709 SELEPRESSIN Vasopressin V1a receptor agonist 2 PubMed PubMed
CHEMBL3545342 RG7314 Vasopressin V1a receptor antagonist 2 Other
CHEMBL3545146 SRX251 Vasopressin V1a receptor antagonist 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166148
Ensembl ENSG00000166148
GO Cellular Component GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005000 (vasopressin receptor activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0017046 (peptide hormone binding)
GO:0031894 (V1A vasopressin receptor binding)
GO:0042277 (peptide binding)
GO Biological Process GO:0001992 (regulation of systemic arterial blood pressure by vasopressin)
GO:0002125 (maternal aggressive behavior)
GO:0003084 (positive regulation of systemic arterial blood pressure)
GO:0006091 (generation of precursor metabolites and energy)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007621 (negative regulation of female receptivity)
GO:0007625 (grooming behavior)
GO:0008015 (blood circulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010033 (response to organic substance)
GO:0010035 (response to inorganic substance)
GO:0010460 (positive regulation of heart rate)
GO:0014049 (positive regulation of glutamate secretion)
GO:0014902 (myotube differentiation)
GO:0019722 (calcium-mediated signaling)
GO:0021537 (telencephalon development)
GO:0030307 (positive regulation of cell growth)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0032849 (positive regulation of cellular pH reduction)
GO:0032870 (cellular response to hormone stimulus)
GO:0035176 (social behavior)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0042631 (cellular response to water deprivation)
GO:0042711 (maternal behavior)
GO:0042713 (sperm ejaculation)
GO:0043084 (penile erection)
GO:0045777 (positive regulation of blood pressure)
GO:0045907 (positive regulation of vasoconstriction)
GO:0051412 (response to corticosterone)
GO:0051970 (negative regulation of transmission of nerve impulse)
GO:1901652 (response to peptide)
Wikipedia Arginine_vasopressin_receptor_1A

Target Cross References - Protein

canSAR P37288
Human Protein Atlas ENSG00000166148
IntAct P37288
Guide to Pharmacology 366
Open Targets ENSG00000166148
PharmGKB PA25187
Pharos P37288 (Tclin)
Reactome R-HSA-388479 (Vasopressin-like receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-5619099 (Defective AVP causes neurohypophyseal diabetes insipidus (NDI).)
UniProt P37288

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001224 (Vprs_V1A_rcpt.)
IPR001817 (Vasoprsn_rcpt.)
IPR015076 (DUF1856.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
PF08983 (DUF1856)

Target Cross References - Structure

PDBe 1YTV
CREDO 1YTV
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