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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1881
Target Type SINGLE PROTEIN
Preferred Name Prostanoid EP2 receptor
Synonyms PGE receptor EP2 subtype | PGE2 receptor EP2 subtype | PTGER2 | Prostaglandin E2 receptor EP2 subtype | Prostanoid EP2 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin E2 receptor EP2 subtype SINGLE PROTEIN P43116

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363068 Prostaglandin E2 receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL495 ALPROSTADIL Prostanoid EP2 receptor agonist 4 DailyMed FDA ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125384
Ensembl ENSG00000125384
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004957 (prostaglandin E receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0032496 (response to lipopolysaccharide)
GO:0032570 (response to progesterone)
GO:0042127 (regulation of cell proliferation)
GO:0071380 (cellular response to prostaglandin E stimulus)
Wikipedia Prostaglandin_E2_receptor

Target Cross References - Protein

canSAR P43116
Human Protein Atlas ENSG00000125384
IntAct P43116
Guide to Pharmacology 341
Open Targets ENSG00000125384
PharmGKB PA287
Pharos P43116 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt D3DSC0 P43116 Q52LG8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001923 (Prostglndn_EP2_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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