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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1878
Target Type SINGLE PROTEIN
Preferred Name Calcium sensing receptor
Synonyms CASR | CaSR | Extracellular calcium-sensing receptor | GPRC2A | PCAR1 | PCaR1 | Parathyroid cell calcium-sensing receptor 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > ion receptor (family c gpcr) > calcium sensing receptor > calcium sensing receptor

Target Components

Component Description Relationship Accession
Extracellular calcium-sensing receptor SINGLE PROTEIN P41180

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1200776 CINACALCET HYDROCHLORIDE Calcium sensing receptor positive allosteric modulator DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000036828
Ensembl ENSG00000036828
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004930 (G-protein coupled receptor activity)
GO Biological Process GO:0001503 (ossification)
GO:0005513 (detection of calcium ion)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007635 (chemosensory behavior)
GO:0009653 (anatomical structure morphogenesis)
GO:0070509 (calcium ion import)
Wikipedia Calcium-sensing_receptor

Target Cross References - Protein

canSAR P41180
CGD Hyperparathyroidism, neonatal; Hypocalcemia, autosomal dominant; Hypocalcemia, autosomal dominant, with Bartter syndrome; Hypocalciuric hypercalcemia, type I; Hyperparathyroidism, neonatal severe primary; Hypoparathyroidism, familial isolated; Hyperparathyroidism, familial primary
Human Protein Atlas ENSG00000036828
Guide to Pharmacology 54 (CaS)
PharmGKB PA26097
Reactome REACT_14797 (Signaling by GPCR.)
UniProt P41180 Q13912 Q16108 Q16109 Q16110 Q16379 Q2M1T0 Q4PJ19

Target Cross References - Domain

InterPro IPR000068 (GPCR_3_Ca_sens_rcpt-rel.)
IPR000337 (GPCR_3.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011500 (GPCR_3_9-Cys_dom.)
IPR017978 (GPCR_3_C.)
IPR017979 (GPCR_3_CS.)
Pfam PF00003 (7tm_3)
PF01094 (ANF_receptor)
PF07562 (NCD3G)
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