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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1876
Target Type SINGLE PROTEIN
Preferred Name Thiazide-sensitive sodium-chloride cotransporter
Synonyms NCC | NCC | Na-Cl cotransporter | Na-Cl symporter | SLC12A3 | Solute carrier family 12 member 3 | TSC | Thiazide-sensitive sodium-chloride cotransporter
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc12 family of cation-coupled chloride transporters

Target Components

Component Description Relationship Accession
Solute carrier family 12 member 3 SINGLE PROTEIN P55017

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL406 INDAPAMIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DailyMed FDA ISBN
CHEMBL435 HYDROCHLOROTHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI DailyMed FDA
CHEMBL842 CHLOROTHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
CHEMBL878 METOLAZONE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI DailyMed
CHEMBL61593 CYCLOTHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
CHEMBL1054 TRICHLORMETHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
CHEMBL1055 CHLORTHALIDONE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI DailyMed
CHEMBL1532 QUINETHAZONE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
CHEMBL1577 METHYCLOTHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI DailyMed
CHEMBL1587 POLYTHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI DailyMed
CHEMBL1684 BENDROFLUMETHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
CHEMBL1763 HYDROFLUMETHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
CHEMBL1200616 CHLOROTHIAZIDE SODIUM Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
CHEMBL1201039 BENZTHIAZIDE Thiazide-sensitive sodium-chloride cotransporter inhibitor 4 DOI
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070915
Ensembl ENSG00000070915
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031982 (vesicle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005515 (protein binding)
GO:0015293 (symporter activity)
GO:0015377 (cation:chloride symporter activity)
GO:0015378 (sodium:chloride symporter activity)
GO:0019899 (enzyme binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0006821 (chloride transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:1902476 (chloride transmembrane transport)
Wikipedia Sodium-chloride_symporter

Target Cross References - Protein

CGD Gitelman syndrome
Human Protein Atlas ENSG00000070915
IntAct P55017
Open Targets ENSG00000070915
PharmGKB PA321
Reactome R-HSA-426117 (Cation-coupled Chloride cotransporters.)
UniProt A8MSJ2 C9JNN9 P55017

Target Cross References - Domain

InterPro IPR002948 (SLC12A3.)
IPR004841 (AA-permease/SLC12A_dom.)
IPR004842 (SLC12A_fam.)
IPR013612 (AA_permease_N.)
IPR018491 (SLC12_C.)
Pfam PF00324 (AA_permease)
PF03522 (SLC12)
PF08403 (AA_permease_N)
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