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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1875
Preferred Name Serotonin 4 (5-HT4) receptor
Synonyms 5-HT-4 | 5-HT4 | 5-hydroxytryptamine receptor 4 | HTR4 | Serotonin receptor 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 4 SINGLE PROTEIN Q13639

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL325109 CLEBOPRIDE Serotonin 4 (5-HT4) receptor agonist 4 PubMed PubMed PubMed PubMed
CHEMBL117287 PRUCALOPRIDE Serotonin 4 (5-HT4) receptor agonist 4 PubMed
CHEMBL1200788 CISAPRIDE Serotonin 4 (5-HT4) receptor agonist 4 DailyMed
CHEMBL1200940 METOCLOPRAMIDE HYDROCHLORIDE Serotonin 4 (5-HT4) receptor agonist 4 ISBN
CHEMBL1516474 TEGASEROD MALEATE Serotonin 4 (5-HT4) receptor partial agonist 4 FDA
CHEMBL2027925 CAPESEROD Serotonin 4 (5-HT4) receptor partial agonist 2 PubMed
CHEMBL2087337 VELUSETRAG Serotonin 4 (5-HT4) receptor agonist 2 PubMed
CHEMBL2103858 NARONAPRIDE Serotonin 4 (5-HT4) receptor agonist 2 PubMed
CHEMBL3545035 REVEXEPRIDE Serotonin 4 (5-HT4) receptor agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164270
Ensembl ENSG00000164270
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001594 (trace-amine receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0032098 (regulation of appetite)
GO:0098664 (G-protein coupled serotonin receptor signaling pathway)
Wikipedia 5-HT4_receptor

Target Cross References - Protein

canSAR Q13639
Human Protein Atlas ENSG00000164270
Guide to Pharmacology 9
Open Targets ENSG00000164270
PharmGKB PA29557
Pharos Q13639 (Tclin)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt C4WYH4 Q13639 Q546Q1 Q684M0 Q712M9 Q96KH9 Q96KI0 Q9H199 Q9NY73 Q9UBM6 Q9UBT4 Q9UE22 Q9UE23 Q9UQR6

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001520 (5HT4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure