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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1873
Target Type SINGLE PROTEIN
Preferred Name Tissue-type plasminogen activator
Synonyms INN=Alteplase | INN=Reteplase | PLAT | Tissue-type plasminogen activator chain A | Tissue-type plasminogen activator chain B | Tissue-type plasminogen activator | t-PA | t-plasminogen activator | tPA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Tissue-type plasminogen activator SINGLE PROTEIN P00750

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1046 AMINOCAPROIC ACID Tissue-type plasminogen activator inhibitor 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104368
Ensembl ENSG00000104368
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0009986 (cell surface)
GO:0030141 (secretory granule)
GO:0045177 (apical part of cell)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0004252 (serine-type endopeptidase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006464 (cellular protein modification process)
GO:0006464 (protein modification process)
GO:0006508 (proteolysis)
GO:0007596 (blood coagulation)
GO:0014909 (smooth muscle cell migration)
GO:0031639 (plasminogen activation)
GO:0042730 (fibrinolysis)
GO:0045861 (negative regulation of proteolysis)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
Wikipedia Tissue_plasminogen_activator

Target Cross References - Protein

canSAR P00750
Human Protein Atlas ENSG00000104368
IntAct P00750
PharmGKB PA33381
UniProt A8K022 B2R8E8 P00750 Q15103 Q503B0 Q6PJA5 Q7Z7N2 Q86YK8 Q9BU99 Q9BZW1

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR000083 (Fibrnctn1.)
IPR000083 (Fibronectin_type1.)
IPR000742 (EGF-like_dom.)
IPR000742 (EGF_3.)
IPR001254 (Peptidase_S1_S6.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR006209 (EGF.)
IPR006210 (EGF-like.)
IPR009003 (Pept_cys/ser_Trypsin-like.)
IPR009003 (Peptidase_S1_PA.)
IPR013032 (EGF-like_CS.)
IPR013032 (EGF-like_reg_CS.)
IPR013806 (Kringle-like.)
IPR016060 (Complement_control_module.)
IPR018056 (Kringle_CS.)
IPR018114 (Peptidase_S1/S6_AS.)
IPR018114 (Peptidase_S1_AS.)
IPR026280 (Tissue_plasm_act.)
Pfam PF00008 (EGF)
PF00039 (fn1)
PF00051 (Kringle)
PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1A5H 1BDA 1PML 1RTF 1TPK 5BRR
CREDO 1A5H 1BDA 1PML 1RTF 1TPK 5BRR
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