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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1870
Target Type SINGLE PROTEIN
Preferred Name Retinoid X receptor beta
Synonyms NR2B2 | Nuclear receptor subfamily 2 group B member 2 | RXRB | Retinoic acid receptor RXR-beta | Retinoid X receptor beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 2

Target Components

Component Description Relationship Accession
Retinoic acid receptor RXR-beta SINGLE PROTEIN P28702

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363070 Retinoid X receptor PROTEIN FAMILY
CHEMBL2363071 Retinoid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204231 ENSG00000206289 ENSG00000227322 ENSG00000228333 ENSG00000231321 ENSG00000235712
Ensembl ENSG00000204231 ENSG00000206289 ENSG00000227322 ENSG00000228333 ENSG00000231321 ENSG00000235712
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004886 (9-cis retinoic acid receptor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0030522 (intracellular receptor signaling pathway)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048384 (retinoic acid receptor signaling pathway)
Wikipedia Retinoid_X_receptor_beta

Target Cross References - Protein

canSAR P28702
Human Protein Atlas ENSG00000204231 ENSG00000206289 ENSG00000227322 ENSG00000228333 ENSG00000231321 ENSG00000235712
IntAct P28702
Guide to Pharmacology 611
Open Targets ENSG00000204231 ENSG00000206289 ENSG00000227322 ENSG00000228333 ENSG00000231321 ENSG00000235712
PharmGKB PA34891
Pharos P28702 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
UniProt P28702 P28703 Q59G65 Q5JP92 Q5STQ1

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt/HNF4.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ
CREDO 1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ
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